Academic Journal
Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
| العنوان: | Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application. |
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| المؤلفون: | Del Río Ibiste, N., Granda Díaz, Rocío, Rodrigo Tapia, Juan Pablo, Menendez, S. T., García Pedrero, Juana María |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2021 |
| المجموعة: | Universidad de Oviedo: RUO |
| مصطلحات موضوعية: | Cáncer de cabeza y cuello |
| الوصف: | This chapter intends to comprehensively and critically review the current state-of-art ion channel dysregulation specifically focusing on head and neck cancers and to formulate the major challenges and research needs to translate this knowledge into clinical application. Based on current reported data, various voltage-gated potassium (Kv) channels (i.e. Kv3.4, Kv10.1 and Kv11.1) have been found frequently aberrantly expressed in HNSCC as well as precancerous lesions and are highlighted as clinically and biologically relevant features in both early stages of tumourigenesis and late stages of disease progression. More importantly, they also emerge as promising candidates as cancer risk markers, tumour markers and potential anti-proliferative and anti-metastatic targets for therapeutic interventions; however, the oncogenic properties seem to be independent of their ion-conducting function. ; This work was supported by grants from the Plan Nacional de I+D+I 2013-2016 from ISCIII (PI16/00280 and PI19/00560) and CIBERONC (CB16/12/00390), the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155) and the FEDER Funding Program from the European Union |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Reviews of Physiology, Biochemistry and Pharmacology; ISCIII/PI16/00280; ISCIII/PI19/00560; CB16/12/00390; IDI2018/155; https://doi.org/10.1007/112_2020_38; http://hdl.handle.net/10651/58156 |
| DOI: | 10.1007/112_2020_38 |
| الاتاحة: | http://hdl.handle.net/10651/58156 https://doi.org/10.1007/112_2020_38 |
| Rights: | © Springer Nature Switzerland AG 2020 |
| رقم الانضمام: | edsbas.53025FAE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/112_2020_38 |
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