Academic Journal
Diagnosis of Hymenoptera venom allergy
| العنوان: | Diagnosis of Hymenoptera venom allergy |
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| المؤلفون: | Biló, B. M., Rueff, F., Mosbech, H., Bonifazi, F., Oude‐Elberink, J. N. G. |
| المصدر: | Allergy ; volume 60, issue 11, page 1339-1349 ; ISSN 0105-4538 1398-9995 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2005 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The purpose of diagnostic procedure is to classify a sting reaction by history, identify the underlying pathogenetic mechanism, and identify the offending insect. Diagnosis of Hymenoptera venom allergy thus forms the basis for the treatment. In the central and northern Europe vespid (mainly Vespula spp.) and honeybee stings are the most prevalent, whereas in the Mediterranean area stings from Polistes and Vespula are more frequent than honeybee stings; bumblebee stings are rare throughout Europe and more of an occupational hazard. Several major allergens, usually glycoproteins with a molecular weight of 10–50 kDa, have been identified in venoms of bees, vespids. and ants. The sequences and structures of the majority of venom allergens have been determined and several have been expressed in recombinant form. A particular problem in the field of cross‐reactivity are specific immunoglobulin E (IgE) antibodies directed against carbohydrate epitopes, which may induce multiple positive test results (skin test, in vitro tests) of still unknown clinical significance. Venom hypersensitivity may be mediated by immunologic mechanisms (IgE‐mediated or non‐IgE‐mediated venom allergy) but also by nonimmunologic mechanisms. Reactions to Hymenoptera stings are classified into normal local reactions, large local reactions, systemic toxic reactions, systemic anaphylactic reactions, and unusual reactions. For most venom‐allergic patients an anaphylactic reaction after a sting is very traumatic event, resulting in an altered health‐related quality of life. Risk factors influencing the outcome of an anaphylactic reaction include the time interval between stings, the number of stings, the severity of the preceding reaction, age, cardiovascular diseases and drug intake, insect type, elevated serum tryptase, and mastocytosis. Diagnostic tests should be carried out in all patients with a history of a systemic sting reaction to detect sensitization. They are not recommended in subjects with a history of large local reaction or no history ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1398-9995.2005.00963.x |
| الاتاحة: | https://doi.org/10.1111/j.1398-9995.2005.00963.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1398-9995.2005.00963.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1398-9995.2005.00963.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.52E42631 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1398-9995.2005.00963.x |
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