Academic Journal
Deep PIM kinase substrate profiling reveals new rational co-therapeutic strategies for acute myeloid leukemia ...
| العنوان: | Deep PIM kinase substrate profiling reveals new rational co-therapeutic strategies for acute myeloid leukemia ... |
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| المؤلفون: | Joglekar, Tejashree, Chin, Alexander, Voskanian-Kordi, Alin, Seungchul, Baek, Raja, Azim, Rege, Apurv, Huang, Weiliang, Kane, Maureen A, Laiho, Marikki, Webb, Thomas, Fan, Xiaoxuan, Rubenstein, Michael, Bieberich, Charles J., Li, Xiang |
| بيانات النشر: | American Society of Hematology |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| الوصف: | Provirus integration site for Moloney murine leukemia virus (PIM) family serine/threonine kinases perform pro-tumorigenic functions in hematologic malignancies and solid tumors by phosphorylating substrates involved in tumor metabolism, cell survival, metastasis, inflammation, and immune cell invasion. However, a comprehensive understanding of PIM kinase functions is currently lacking. Multiple small molecule PIM kinase inhibitors are currently being evaluated as co-therapeutics in cancer patients. To further illuminate PIM kinase functions in cancer, we deeply profiled PIM1 substrates using the reverse in-gel kinase assay to identify downstream cellular processes targetable with small molecules. Pathway analyses of putative PIM substrates nominated RNA splicing and rRNA processing as PIM-regulated cellular processes. PIM inhibition elicited reproducible splicing changes in PIM-inhibitor-responsive acute myeloid leukemia (AML) cell lines. PIM inhibitors synergized with splicing modulators targeting splicing ... |
| نوع الوثيقة: | text |
| اللغة: | English |
| DOI: | 10.13016/m2fkyb-awsg |
| الاتاحة: | https://dx.doi.org/10.13016/m2fkyb-awsg https://mdsoar.org/handle/11603/34606 |
| Rights: | Creative Commons Attribution Non Commercial No Derivatives 4.0 International ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode ; cc-by-nc-nd-4.0 |
| رقم الانضمام: | edsbas.52E34DC6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.13016/m2fkyb-awsg |
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