Academic Journal
Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue
| العنوان: | Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue |
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| المؤلفون: | Fernandes, João S., Gentile, Piergiorgio, Pires, R. A., Reis, R. L., Hatton, Paul V. |
| بيانات النشر: | Elsevier 1 |
| سنة النشر: | 2017 |
| المجموعة: | Universidade of Minho: RepositóriUM |
| مصطلحات موضوعية: | Bioglasses, Glass-ceramics, Antibacterial, Bone, Multifunctional biomaterials, Science & Technology |
| الوصف: | "Article in Press" ; Bioactive glasses (BGs) and related glass-ceramic biomaterials have been used in bone tissue repair for over 30 years. Previous work in this field was comprehensively reviewed including by their inventor Larry Hench, and the key features and properties of BGs are well understood. More recently, attention has focused on their modification to further enhance the osteogenic behaviour, or further compositional changes that may introduce additional properties such as antimicrobial activity. Evidence is emerging that BGs and related glass-ceramics may be modified in such a way as to simultaneously introduce more than one desirable property. The aim of this review is therefore to consider the evidence that these more recent inorganic modifications to glass and glass-ceramic biomaterials are effective, and whether or not these new compositions represent sufficiently versatile systems to underpin the development of a new generation of truly multifunctional biomaterials to address pressing clinical needs in orthopaedic and dental surgery. Indeed, a number of classical glass compositions exhibited antimicrobial activity, however the structural design and the addition of specific ions, i.e. Ag+, Cu+, and Sr2+, are able to impart a multifunctional character to these systems, through the combination of, for example, bioactivity with bactericidal activity. ; João S. Fernandes gratefully acknowledge financial support from Portuguese Foundation for Science and Technology (PhD grant BD/73162/2010). This work was also supported by the European Union H2020 grant number H2020-TWINN-2015- 692333 – CHEM2NATURE and grant number H2020- WIDESPREAD-2014-2-668983 – FORECAST. During the preparation of this review, João S. Fernandes was also a visiting PhD student at the University of Sheffield working on a project associated with MeDe Innovation (EPSRC grant EP/K029592/1) alongside Piergiorgio Gentile and Paul V. Hatton. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1742-7061 1878-7568 |
| Relation: | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73162%2F2010/PT; Fernandes J. S., Gentile P., Pires R. A., Reis R. L., Hatton P. V. Multifunctional bioactive glass and glass-ceramic biomaterials with antibacterial properties for repair and regeneration of bone tissue, Acta Biomaterialia, doi:10.1016/j.actbio.2017.06.046, 2017; https://hdl.handle.net/1822/51324 |
| DOI: | 10.1016/j.actbio.2017.06.046 |
| الاتاحة: | https://hdl.handle.net/1822/51324 https://doi.org/10.1016/j.actbio.2017.06.046 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.52DFF75A |
| قاعدة البيانات: | BASE |
| تدمد: | 17427061 18787568 |
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| DOI: | 10.1016/j.actbio.2017.06.046 |