Academic Journal
Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.
| العنوان: | Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes. |
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| المؤلفون: | Ruan, Yue, Bally, Lia, Thabit, Hood, Leelarathna, Lalantha, Hartnell, Sara, Tauschmann, Martin, Wilinska, Malgorzata E, Evans, Mark L, Mader, Julia K, Kojzar, Harald, Dellweg, Sibylle, Benesch, Carsten, Arnolds, Sabine, Pieber, Thomas R, Hovorka, Roman |
| المصدر: | Ruan, Yue; Bally, Lia; Thabit, Hood; Leelarathna, Lalantha; Hartnell, Sara; Tauschmann, Martin; Wilinska, Malgorzata E; Evans, Mark L; Mader, Julia K; Kojzar, Harald; Dellweg, Sibylle; Benesch, Carsten; Arnolds, Sabine; Pieber, Thomas R; Hovorka, Roman (2018). Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes. Diabetes, obesity & metabolism, 20(8), pp. 2004-2008. Wiley 10.1111/dom.13304 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | Glucose excursion was assessed prior to and post hypoglycaemia to increase understanding of hypoglycaemia incidence and recovery during hybrid closed-loop insulin delivery. We retrospectively analysed data from 60 adults with type 1 diabetes who received, in a crossover randomized design, day-and-night hybrid closed-loop insulin delivery and insulin pump therapy, the latter with or without real-time continuous glucose monitoring. Over 4-week study periods, we identified hypoglycaemic episodes, defined as sensor glucose <3.0 mmol/L, and analysed sensor glucose relative to the onset of hypoglycaemia. We identified 377 hypoglycaemic episodes during hybrid closed-loop intervention vs 662 during control intervention (P < .001), with a predominant reduction of nocturnal hypoglycaemia. The slope of sensor glucose prior to hypoglycaemia was steeper during closed-loop intervention than during control intervention (P < .01), while insulin delivery was reduced (P < .01). During both day and night, participants recovered from hypoglycaemia faster when treated by closed-loop intervention. At 120 minutes post hypoglycaemia, sensor glucose levels were higher during closed-loop intervention compared to the control period (P < .05). In conclusion, closed-loop intervention reduces the risk of hypoglycaemia, particularly overnight, with swift recovery from hypoglycaemia leading to higher 2-hour post-hypoglycaemia glucose levels. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://boris.unibe.ch/123194/ |
| الاتاحة: | https://boris.unibe.ch/123194/1/Ruan-2018-Hypoglycaemia%20incidence%20and%20recovery.pdf https://boris.unibe.ch/123194/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.52CE7B55 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |