Academic Journal
Effect of N G ‐nitro‐L‐arginine methyl ester a nitric oxide synthase inhibitor on neurotransmitter receptor systems in aged rats
| العنوان: | Effect of N G ‐nitro‐L‐arginine methyl ester a nitric oxide synthase inhibitor on neurotransmitter receptor systems in aged rats |
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| المؤلفون: | Araki, Tsutomu, Oshima, Yoshiteru, Kato, Hiroyki, Shuto, Katsuro, Itoyama, Yasuto |
| المصدر: | European Journal of Neurology ; volume 5, issue 6, page 601-608 ; ISSN 1351-5101 1468-1331 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1998 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | In order to examine the effect of age and nitric oxide synthase inhibitor N G ‐nitro‐L‐arginine methl ester ( l ‐NAME) we studied the changes on major neurotransmitter receptor systems in 6 (adult and 24‐month‐old (aged) Fischer male rats using receptor autoradiography. l ‐name was administrated intraperitoneally in aged rats once a day for 4 weeks. [ 3 H]QNB (quinuclidinyl benzilate) 3 HC (hemicholinium‐3) [ 3 H] muscimol 3 H] SCH 23390 ([ N ‐methyl‐ 3 H] N ‐methyl‐ 3 H] R [+]‐8‐chloro‐2 3 4 5‐tetrahydro‐3‐methyl‐5‐phenyl‐7‐il‐benzazepine) 3 H] mazindol were used as markers of muscarinic acetylcholine receptors high‐high‐affinity choline uptake sites GABA A (γ‐aminobutyric acid (SP2) A ) receptors dopamine D 1 receptors dopamine D 2 receptors and dopamine uptake sites respectively. The age‐related change in 3 H muscimol binding in the brain was more pronounced than that in [ 3 H] QNB 3 H]HC 3 H]SCH 23390 3 H] nemonapride and 3 H] nemonapride and 3 H] mazindol binding.Chronic treatment (4 weeks) with l ‐NAME caused no significant changes in [sp1) 3 H] muscimol 3 H SCH 23390 and [ 3 H] nemonapride binding in most areas of aged rat brain as compared with vehicle‐treated aged animals. However chronic treatment with l ‐NAME caused a significant reduction in 3 H] HC and 3 H] mazindol binding in any brain regions of aged rats in comparison with the vehicle‐treated aged animals. These results demonstrate that the GABAergic system is more susceptible to aging processes than cholinergic and dopaminergic systems in teh brain. Furthermore our findings suggest that nitric oxide may play some role in the regulation of choline uptake and dopamine uptake systems during aging processes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1468-1331.1998.560601.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1468-1331.1998.560601.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1468-1331.1998.560601.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1468-1331.1998.560601.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.525F43AD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1468-1331.1998.560601.x |
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