Academic Journal
Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock
| العنوان: | Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock |
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| المؤلفون: | Vignon, Philippe, Charron, Cyril, Legras, Annick, Musset, Frédérique, Slama, Michel, Prat, Gwenaël, Silva, Stein, Vandroux, David, Müller, Grégoire, Levy, Bruno, Boissier, Florence, Evrard, Bruno, Goudelin, Marine, Mankikian, Stéfan, Nay, Mai-Anh, Jabot, Julien, Riu, Béatrice, Bailly, Pierre, Maizel, Julien, Léger, Julie, Vieillard-Baron, Antoine |
| المساهمون: | Service de Réanimation Polyvalente CHU Limoges, CHU Limoges, Centre d'Investigation Clinique de Limoges (CIC1435), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Hôpital Ambroise Paré AP-HP, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d’Investigation Clinique Tours CIC 1415 (CIC), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Institut National de la Santé et de la Recherche Médicale (INSERM), Médecine Intensive-Réanimation CHU Amiens, CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Neurochirurgie Hôpital Gui de Chauliac, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Hôpital Gui de Chauliac CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), Institut de Recherche pour le Développement (IRD)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Service de chirurgie cardiaque CHU Limoges, Membrane Signalling and Inflammation in reperfusion Injuries (ISCHEMIA), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional d'Orléans (CHRO), Service de Réanimation Médicale CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402), Université de Poitiers = University of Poitiers (UP)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Dupuytren CHU Limoges, CHU Trousseau Tours, Centre hospitalier Félix-Guyon Saint-Denis, La Réunion, Pôle Anesthésie Réanimation CHU de Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hopital de Bohars - CHRU Brest (CHU - BREST), PRODIASYS study registered on ClinicalTrials (September 27, 2016, number NCT02918214) |
| المصدر: | ISSN: 0342-4642. |
| بيانات النشر: | CCSD Springer Verlag |
| سنة النشر: | 2025 |
| مصطلحات موضوعية: | Left ventricular diastolic function, Prognosis, Sepsis, Septic shock, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| الوصف: | International audience ; Purpose: Prognostic impact of left ventricular diastolic dysfunction (LVDD) in septic shock patients has not been determined using current diagnostic guidelines. We assessed the relation between LVDD during the first 3 days following intensive care unit (ICU) admission for septic shock and Day-28 mortality.Methods: This prospective, multicenter, observational study enrolled 402 patients (age: 63 ± 13 year; 59% male; SAPS II: 59 ± 20; SOFA: 9.4 ± 3.6; mechanical ventilation: 74%) with septic shock (Sepsis-3 definition). Patients were echocardiographically assessed within 12 h after admission (Day 1), on Day 2, Day 3, at ICU and at hospital discharge (or Day 28 whichever occurred first), using 2016 American-European guidelines.Results: LVDD was present at least once between Day 1 and 3 in 304 patients (76%), and in 56% and 44% of patients at ICU discharge and on Day 28 (or hospital discharge), respectively (43% of patients with follow-up). Seventy-eight of 172 patients (45%) exhibited similar LV diastolic properties throughout the study period while 58 patients (34%) improved their LVDD at follow-up (lower grade: n = 9, regression: n = 49). Day-28 mortality was not statistically different between patients with and without LVDD (80/304 [26%] vs. 25/88 [28%]; OR: 0.900 [0.530-1.527]; p = 0.696). Similar results were obtained when adjusting the multivariate model on SAPSII or SOFA score on admission, together with fluid balance during the first three days of ICU stay (OR: 0.838 [0.471-1.491]: p = 0.547 and OR: 0.887 [0.513-1.534]: p = 0.668, respectively).Conclusion: LVDD was highly prevalent in patients with septic shock but not associated with mortality. It appeared improving in one-third of survivors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00134-024-07748-2 |
| الاتاحة: | https://u-picardie.hal.science/hal-04877407 https://doi.org/10.1007/s00134-024-07748-2 |
| رقم الانضمام: | edsbas.523D4A69 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00134-024-07748-2 |
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