Academic Journal
Prevalence and Associated Factors of optrA-Positive-Enterococcus faecalis in Different Reservoirs around Farms in Vietnam
| العنوان: | Prevalence and Associated Factors of optrA-Positive-Enterococcus faecalis in Different Reservoirs around Farms in Vietnam |
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| المؤلفون: | Ha, Hoang Thi An, Nguyen, Phuong Thi Lan, Hung, Tran Thi Mai, Tuan, Le Anh, Thuy, Bui Thanh, Lien, Tran Hoang My, Thai, Pham Duy, Thanh, Nguyen Ha, Bich, Vu Thi Ngoc, Anh, Tran Hai, Hanh, Ngo Thi Hong, Minh, Nguyen Thi, Thanh, Duy Pham, Mai, Si-Nguyen, The, Hao Chung, Trung, Nguyen Vu, Thu, Nguyen Hoai, Duong, Tran Nhu, Anh, Dang Duc, Ngoc, Pham Thi, Bañuls, Anne-Laure, Choisy, Marc, van Doorn, H. Rogier, Suzuki, Masato, Hoang, Tran Huy |
| المساهمون: | Hanoï Medical University, National Institute of Hygiene and Epidemiology / Institut National d'Hygiène et d'Épidémiologie Hanoi, Vietnam (NIHE), Pasteur Network (Réseau International des Instituts Pasteur), Oxford University Clinical Research Unit Hanoi (OUCRU), Nuffield Department of Clinical Medicine Oxford, University of Oxford, London School of Hygiene and Tropical Medicine (LSHTM), Institut Pasteur d'Ho Chi Minh Ville, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM), Oxford University Clinical Research Unit Ho Chi Minh City (OUCRU) |
| المصدر: | EISSN: 2079-6382 ; Antibiotics ; https://hal.science/hal-04510292 ; Antibiotics, 2023, 12 (6), pp.954. ⟨10.3390/antibiotics12060954⟩ |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | E. faecalis, farms, flies, linezolid resistance, optrA livestock, Vietnam, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Linezolid is an antibiotic of last resort for the treatment of infections caused by Gram-positive bacteria, including vancomycin-resistant enterococci. Enterococcus faecalis, a member of enterococci, is a significant pathogen in nosocomial infections. E. faecalis resistance to linezolid is frequently related to the presence of optrA, which is often co-carried with fex, phenicol exporter genes, and erm genes encoding macrolide resistance. Therefore, the common use of antibiotics in veterinary might promote the occurrence of optrA in livestock settings. This is a cross-sectional study aiming to investigate the prevalence of optrA positive E. faecalis (OPEfs) in 6 reservoirs in farms in Ha Nam province, Vietnam, and its associated factors and to explore genetic relationships of OPEfs isolates. Among 639 collected samples, the prevalence of OPEfs was highest in flies, 46.8% (51/109), followed by chickens 37.3% (72/193), dogs 33.3% (17/51), humans 18.7% (26/139), wastewater 16.4% (11/67) and pigs 11.3%, (14/80). The total feeding area and total livestock unit of the farm were associated with the presence of OPEfs in chickens, flies, and wastewater. Among 186 OPEfs strains, 86% were resistant to linezolid. The presence of optrA was also related to the resistant phenotype against linezolid and levofloxacin of E. faecalis isolates. Close genotypic relationships identified by Pulsed Field Gel Electrophoresis between OPEfs isolates recovered from flies and other reservoirs including chickens, pigs, dogs, and wastewater suggested the role of flies in the transmission of antibiotic-resistant pathogens. These results provided warnings of linezolid resistance although it is not used in livestock. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | IRD: fdi:010088195 |
| DOI: | 10.3390/antibiotics12060954 |
| الاتاحة: | https://hal.science/hal-04510292 https://hal.science/hal-04510292v1/document https://hal.science/hal-04510292v1/file/antibiotics-12-00954.pdf https://doi.org/10.3390/antibiotics12060954 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.521DC0EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/antibiotics12060954 |
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