Academic Journal
Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target ...
| العنوان: | Merging Orthovoltage X-Ray Minibeams spare the proximal tissues while producing a solid beam at the target ... |
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| المؤلفون: | Dilmanian, F. Avraham, Krishnan, Sunil, McLaughlin, William E., Lukaniec, Brendan, Baker, Jameson T., Ailawadi, Sandeep, Hirsch, Kara N., Cattell, Renee F., Roy, Rahul, Helfer, Joel, Kruger, Kurt, Spuhler, Karl, He, Yulun, Tailor, Ramesh, Vassantachart, April, Heaney, Dakota C., Zanzonico, Pat, Gobbert, Matthias K., Graf, Jonathan S., Nassimi, Jessica R., Fatemi, Nasrin N., Schweitzer, Mark E., Bangiyev, Lev, Eley, John G. |
| بيانات النشر: | Springer Nature Publishing AG. |
| سنة النشر: | 2019 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | biophysical methods, characterization and analytical techniques, physiology, preclinical research, radiotherapy |
| الوصف: | Conventional radiation therapy of brain tumors often produces cognitive deficits, particularly in children. We investigated the potential efficacy of merging Orthovoltage X-ray Minibeams (OXM). It segments the beam into an array of parallel, thin (~0.3 mm), planar beams, called minibeams, which are known from synchrotron x-ray experiments to spare tissues. Furthermore, the slight divergence of the OXM array make the individual minibeams gradually broaden, thus merging with their neighbors at a given tissue depth to produce a solid beam. In this way the proximal tissues, including the cerebral cortex, can be spared. Here we present experimental results with radiochromic films to characterize the method’s dosimetry. Furthermore, we present our Monte Carlo simulation results for physical absorbed dose, and a first-order biologic model to predict tissue tolerance. In particular, a 220-kVp orthovoltage beam provides a 5-fold sharper lateral penumbra than a 6-MV x-ray beam. The method can be implemented in ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.13016/m2ikwy-jihx |
| الاتاحة: | https://dx.doi.org/10.13016/m2ikwy-jihx http://mdsoar.org/handle/11603/12892 |
| Rights: | Creative Commons Attribution 4.0 International ; Attribution 4.0 International (CC BY 4.0) ; This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0 |
| رقم الانضمام: | edsbas.51F3C406 |
| قاعدة البيانات: | BASE |
| DOI: | 10.13016/m2ikwy-jihx |
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