Academic Journal
Development of Cyclodextrin-Based Mono and Dual Encapsulated Powders by Spray Drying for Successful Preservation of Everlasting Flower Extract
| العنوان: | Development of Cyclodextrin-Based Mono and Dual Encapsulated Powders by Spray Drying for Successful Preservation of Everlasting Flower Extract |
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| المؤلفون: | Ćujić Nikolić, Nada, Jovanović, Miloš, Radan, Milica, Lazarević, Zorica, Bigović, Dubravka, Marković, Smilja, Jovanović Lješković, Nataša, Šavikin, Katarina |
| المصدر: | Pharmaceutics |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | DAIS repository (Digital Archive of the Publications of the Serbian Academy of Sciences and Arts - SASA) / Дигитални архив издања САНУ |
| مصطلحات موضوعية: | everlasting flowers, Helichrysum plicatum DC, spray drying, dual-microencapsulation, cyclodextrins, particle characterization, phenolics |
| الوصف: | The study aimed to develop encapsulation systems to maintain the preservation of everlasting (Helichrysum plicatum) flower extract polyphenols. Spray-dried encapsulates were formulated using β-cyclodextrin (BCD) and 2-hydroxypropyl-β-cyclodextrin (HPBCD) as supramolecular hosts, and their macromolecule mixtures with the conventional carriers, maltodextrin (MD) and whey protein (WP). The obtained microparticles were comparatively assessed regarding technological, physicochemical, and phytochemical properties. The highest yields were achieved by combining cyclodextrins with whey protein (73.96% for WP+BCD and 75.50% for WP+HPBCD compared to 62.48% of pure extract). The extract–carrier interactions and thermal stability were evaluated by FTIR and DSC analysis, suggesting successful entrapment within the carriers. Carriers reduced the particle diameter (3.99 to 4.86 μm compared to 6.49 μm of pure extract), classifying all encapsulates as microsystems. Carrier blends made the particle size distribution uniform, while SEM analysis revealed the production of more spherical and less aggregated particles. The HPBCD provided the highest encapsulation efficiency, with the highest content of detected aglycones and slightly lower values of their glycosylated forms. An analysis of the dual macromolecule encapsulation systems revealed the highest bioactive preservation potential for SHE+MD+BCD and SHE+WP+HPBCD. Overall, macromolecule combinations of cyclodextrins and conventional biopolymers in the spray-drying process can enhance the functional properties of H. plicatum extract. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | info:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS//; info:eu-repo/grantAgreement/MESTD/inst-2020/200175/RS//; Provincial Secretariat for Higher Education and Scientific Research, Autonomous Province of Vojvodina, Republic of Serbia, Grant Number: 142-451-3174/2022-01/01; https://dais.sanu.ac.rs/123456789/17217; 001278560500001; https://hdl.handle.net/21.15107/rcub_dais_17217 |
| DOI: | 10.3390/pharmaceutics16070861 |
| الاتاحة: | https://dais.sanu.ac.rs/123456789/17217 https://doi.org/10.3390/pharmaceutics16070861 https://hdl.handle.net/21.15107/rcub_dais_17217 |
| Rights: | openAccess ; https://creativecommons.org/licenses/by/4.0/ ; BY |
| رقم الانضمام: | edsbas.51CEB9B6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pharmaceutics16070861 |
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