التفاصيل البيبلوغرافية
| العنوان: |
Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis |
| المؤلفون: |
Zaro, Maria Jose, Bortolotti, Ana, Riafrecha, Leonardo Ezequiel, Concellón, Analía, Morbidoni, Héctor Ricardo, Colinas, Pedro Alfonso |
| بيانات النشر: |
Taylor & Francis Ltd |
| المجموعة: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: |
ABTS, DPPH, MYCOBACTERIUM TUBERCULOSIS, https://purl.org/becyt/ford/1.4, https://purl.org/becyt/ford/1 |
| الوصف: |
During the treatment of tuberculosis infection, oxidative stress due to anti-tubercular drugs may result in tissue inflammation. It was suggested that treatment with antioxidant drugs could be beneficial as an adjunct to anti-tuberculosis drug therapy. Recently our group has shown that several C-glycosides are inhibitors of Mycobacterium tuberculosis β-carbonic anhydrases (CAs, EC 4.2.1.1). In an effort to develop novel chemotherapeutic agents against tuberculosis, the anti-tubercular and antioxidant activities of a series of C-glycosides containing the phenol or the methoxyaryl moiety were studied. Many compounds showed inhibition of growth of M. tuberculosis H37Rv strain and good antioxidant ability. A glycomimetic incorporating the 3-hydroxyphenyl moiety showed the best activity profile and therefore this functionality represents lead for the development of novel anti-tubercular agents with dual mechanisms of action. ; Fil: Zaro, Maria Jose. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina ; Fil: Bortolotti, Ana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas. Cátedra de Microbiología, Parasitología y Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina ; Fil: Riafrecha, Leonardo Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Laboratorio de Estudio de Compuestos Orgánicos; Argentina ; Fil: Concellón, Analía. Provincia de Buenos Aires. ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1475-6366 |
| Relation: |
http://hdl.handle.net/11336/112280; Zaro, Maria Jose; Bortolotti, Ana; Riafrecha, Leonardo Ezequiel; Concellón, Analía; Morbidoni, Héctor Ricardo; et al.; Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis; Taylor & Francis Ltd; Journal of Enzyme Inhibition and Medicinal Chemistry; 31; 5-2016; 1726-1730; CONICET Digital; CONICET |
| الاتاحة: |
http://hdl.handle.net/11336/112280 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc/2.5/ar/ |
| رقم الانضمام: |
edsbas.51A033C8 |
| قاعدة البيانات: |
BASE |