Dissertation/ Thesis
FTIR imaging: a potential new tool to characterize cancer cells and tumor infiltrating lymphocytes in human breast cancer ; Caractérisation des cellules tumorales et des lymphocytes infiltrant les tumeurs mammaires par imagerie infrarouge
| العنوان: | FTIR imaging: a potential new tool to characterize cancer cells and tumor infiltrating lymphocytes in human breast cancer ; Caractérisation des cellules tumorales et des lymphocytes infiltrant les tumeurs mammaires par imagerie infrarouge |
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| المؤلفون: | Verdonck, Magali |
| المساهمون: | Sotiriou, Christos, Goormaghtigh, Erik, Raussens, Vincent, Vandenbranden, Michel, Wood, Bayden, Heraud, Philip, Willard-Gallo, Karen |
| بيانات النشر: | Universite Libre de Bruxelles Université libre de Bruxelles, Faculté des Sciences – Ecole Interfacultaire des Bioingénieurs, Bruxelles |
| سنة النشر: | 2015 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Agronomie générale, Breast -- Cancer -- Diagnosis, Fourier transform infrared spectroscopy, Sein -- Cancer -- Dépistage, Spectroscopie infrarouge par transformée de Fourier, TILs, Breast cancer/Cancer du sein, Lymphocytes, infrared spectroscopy/spectroscopie infrarouge |
| الوصف: | Breast cancer is the most common cancer in women. It is a highly heterogeneous disease in terms of histology, therapeutic response and patient outcomes. Early and accurate detection of breast cancer is crucial as the patient prognosis varies greatly depending on the diagnosis of the disease. Nonetheless current breast cancer classification methods fail to precisely sub-classify the disease, resulting in potential inadequate therapeutic management of patients and subsequent poor clinical outcomes. Substantial effort is therefore put in cancer research to develop methods and find new biomarkers efficiently identifying and characterizing breast tumor cells. Moreover it is now well-recognized that the intensive cross-talk between cancer cells and their microenvironment (including non-tumor cells) highly influences cancer progression. Recently, a growing body of clinical evidence reported the prognostic and predictive value associated with the presence of tumor infiltrating lymphocytes (TILs) in the microenvironment of breast tumors. Although the evaluation of TILs would be of great value for the management of patients and the development of new immunotherapies, it is currently not assessed in routine practice. Furthermore Fourier transform infrared (FTIR) imaging has shown its usefulness to study a panel of human cancers. Infrared (IR) spectroscopy coupled to microscopy provides images composed of multiple spectra reflecting the biochemical composition and subtle modifications within biological samples. IR imaging therefore provides useful information to improve breast cancer identification and characterization. The ultimate aim of this thesis is to improve breast cancer diagnosis using FTIR imaging to better identify and characterize cancer cells and the tumor microenvironment of breast cancers. In a first step we carried out a feasibility study aiming at evaluating the impact of the sample fixation process on IR spectra. While spectra were undeniably influenced by this biochemical alteration, our results indicated ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | 2 full-text file(s): application/pdf | application/pdf |
| اللغة: | English |
| Relation: | local/bictel.ulb.ac.be:ULBetd-06252015-211532; local/ulbcat.ulb.ac.be:1100827; https://dipot.ulb.ac.be/dspace/bitstream/2013/209047/1/e49323d8-2b2a-40c0-8195-a67baf0447df.txt; https://dipot.ulb.ac.be/dspace/bitstream/2013/209047/4/9b518566-f712-447c-af62-57c01ef0eef2.txt; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209047 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209047 https://dipot.ulb.ac.be/dspace/bitstream/2013/209047/1/e49323d8-2b2a-40c0-8195-a67baf0447df.txt https://dipot.ulb.ac.be/dspace/bitstream/2013/209047/4/9b518566-f712-447c-af62-57c01ef0eef2.txt |
| رقم الانضمام: | edsbas.5161B41C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |