Academic Journal
Cutibacterium acnes as an overseen autoimmunity trigger: Unearthing heat-shock driven molecular mimicry
| العنوان: | Cutibacterium acnes as an overseen autoimmunity trigger: Unearthing heat-shock driven molecular mimicry |
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| المؤلفون: | Repac, Jelena, Božić, Bojan, Božić Nedeljković, Biljana |
| بيانات النشر: | Elsevier France ^Editions Scientifiques et Medicales |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Cutibacterium acnes, Heat Shock protein, Juvenile Idiopathic Arthritis, Molecular mimicry, Rheumatoid Arthritis, Type 1 Diabetes |
| الوصف: | Cutibacterium acnes, common resident of the human skin, can establish both commensal and pathogenic relations with the human host; however, long-term consequences of C. acnes-induced inflammation remained un(der)explored. To infer the capacity of triggering autoimmunity in humans via molecular mimicry, a comprehensive immunoinformatics analysis of the experimentally characterized C. acnes proteome was performed. The protocol included homology screening between the C. acnes and the human proteome, and validation of shared specificity regions against the collection of experimentally characterized T-cell epitopes, related to autoimmunity. To obtain highly reliable predictions, the results were subjected to additional cross-validation by a dedicated MHC-restriction analysis, including a docking study of C. acnes mimotopes and human counterparts with the highest degree of sequence similarity to MHCII molecules representing the highest risk for detected autoimmune pathologies. Due to mimicking of highly immunogenic, but also evolutionary conserved autoantigens from the Heat Shock protein family, association between C. acnes and the pathogenesis of highly incident autoimmune diseases: Type 1 Diabetes, Rheumatoid Arthritis, and Juvenile Idiopathic Arthritis, was found. To the best of our knowledge, this study is the first one to provide preliminary information and a mechanistic link on the putative involvement of C. acnes in the pathogenesis of autoimmunity in humans. ; M21 ; 5.8 ; 105420 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1286-4579 12864579 |
| Relation: | Microbes and infection; https://biore.bio.bg.ac.rs/handle/123456789/7279 |
| DOI: | 10.1016/j.micinf.2024.105420 |
| الاتاحة: | https://biore.bio.bg.ac.rs/handle/123456789/7279 https://doi.org/10.1016/j.micinf.2024.105420 |
| Rights: | none |
| رقم الانضمام: | edsbas.51376663 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 12864579 |
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| DOI: | 10.1016/j.micinf.2024.105420 |