Academic Journal
Dipeptidyl peptidase 4 inhibitor sitagliptin decreases myocardial fibrosis and modulates myocardial insulin signaling in a swine model of chronic myocardial ischemia.
| العنوان: | Dipeptidyl peptidase 4 inhibitor sitagliptin decreases myocardial fibrosis and modulates myocardial insulin signaling in a swine model of chronic myocardial ischemia. |
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| المؤلفون: | Harris, Dwight D, Sabe, Sharif A, Broadwin, Mark, MD, Stone, Chris, Bellam, Krishna, Malhotra, Akshay, Abid, M Ruhul, Sellke, Frank W |
| المصدر: | Fellows and Residents |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2024 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Animals, Sitagliptin Phosphate, Fibrosis, Dipeptidyl-Peptidase IV Inhibitors, Signal Transduction, Insulin, Myocardial Ischemia, Disease Models, Animal, Swine, Myocardium, Chronic Disease, Fellows and Residents, Medicine and Health Sciences |
| الوصف: | Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the underlying mechanisms remain unclear. We therefore sought to evaluate the effect of the DPP-4 inhibitor sitagliptin on myocardial fibrosis, and insulin signaling in chronic myocardial ischemia using a swine model. An ameroid constrictor placement on the left coronary circumflex artery of thirteen Yorkshire swine to model chronic myocardial ischemia. After two weeks of recovery, swine were assigned to one of two groups: control (CON, n = 8), or sitagliptin 100mg daily (SIT, n = 5). After 5 weeks of treatment, the swine underwent terminal harvest with collection of myocardial tissue. Fibrosis was quantified using Masson's trichrome. Protein expression was quantified by Immunoblotting. Trichrome stain demonstrated a significant decrease in perivascular and interstitial fibrosis in the SIT group relative to CON (all p |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://scholarlyworks.lvhn.org/fellows-residents/646; https://pubmed.ncbi.nlm.nih.gov/39074126/ |
| الاتاحة: | https://scholarlyworks.lvhn.org/fellows-residents/646 https://pubmed.ncbi.nlm.nih.gov/39074126/ |
| رقم الانضمام: | edsbas.50E0FECC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |