Academic Journal
in h
| العنوان: | in h |
|---|---|
| المؤلفون: | Gang G. Wang, C. David Allis |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.biochem.uci.edu/resources/steffan/Part II, review.pdf. |
| المجموعة: | CiteSeerX |
| الوصف: | nte also remains an intriguing possibility that certain chro-Review TRENDS in Molecular Medicine Vol.13 No.9structures) to allow access to associated DNA segments. Over the last few decades, cancer research has delineated six essential pathways whose alterations col-lectively dictate malignant growth: self-sufficiency in growth signals, insensitivity to growth-inhibitory signals, evasion of apoptosis, limitless replicative potential, sus-tained angiogenesis and tissue invasion and metastasis [1]. Traditional cancer research has focused on identifi-cation of genetic mutations, such as amplifications, deletions and point mutations, that target the molecular players involved in these pathways. It has revolutionized our understanding of the molecular mechanisms in cancer matin-remodeling complexes exchange histone dimer pairs in nucleosomes as a means of introducing new epigenetic ‘signatures ’ by altering the landscape of their post-transla-tional modifications (see Figure 1 and part I of this series [6]). ATP-dependent chromatin-remodeling enzymes and their functions ATP-dependent chromatin-remodeling enzymes, which are highly conserved in organisms from yeast to humans, are similar to the SNF2 (sucrose non-fermenting 2) family of DNA translocases and all contain a catalytic ATPase subunit [7]. These ATPase machineries utilize the energy of ATP hydrolysis to mobilize nucleosomes along DNA, evict histones off DNA or promote the exchange of histone |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.457.9329; http://www.biochem.uci.edu/resources/steffan/Part II, review.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.457.9329 http://www.biochem.uci.edu/resources/steffan/Part II, review.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.5097D2F6 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |