Academic Journal
International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire
| العنوان: | International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire |
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| المؤلفون: | Sodergren, Samantha, Johnson, Colin, Darlington, Anne-Sophie, Nugent, Karen, Gilbert, Alexandra, Cocks, Kim, Guren, Marianne Grønlie, Rivin del Campo, Eleonor, Brennan, Christine, Christensen, Peter, Chu, William, Chung, Hans, Dennis, Kristopher, Gilbert, Duncan C., Glynne-Jones, Rob, Jefford, Michaeel, Johansson, Mia, Johnsson, Anders, Juul, Therese, Kardamakis, Dimitrios, Lai-Kwon, Julia, McFarlane, Vicky, Miguel, Isalia M.C., Peters, Femke, Riechelmann, Rachel P., Turhal, Nazim S., Wong, Shun, Vassiliou, Vassilios |
| سنة النشر: | 2022 |
| المجموعة: | University of Southampton: e-Prints Soton |
| الوصف: | Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. Methods and Materials: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. Results: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. Conclusions: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://eprints.soton.ac.uk/472918/1/International_validation_of_the_EORTC_QLQ_ANL27.docx; Sodergren, Samantha, Johnson, Colin, Darlington, Anne-Sophie, Nugent, Karen, Gilbert, Alexandra, Cocks, Kim, Guren, Marianne Grønlie, Rivin del Campo, Eleonor, Brennan, Christine, Christensen, Peter, Chu, William, Chung, Hans, Dennis, Kristopher, Gilbert, Duncan C., Glynne-Jones, Rob, Jefford, Michaeel, Johansson, Mia, Johnsson, Anders, Juul, Therese, Kardamakis, Dimitrios, Lai-Kwon, Julia, McFarlane, Vicky, Miguel, Isalia M.C., Nugent, Karen, Peters, Femke, Riechelmann, Rachel P., Turhal, Nazim S., Wong, Shun and Vassiliou, Vassilios (2022) International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire. International Journal of Radiation Oncology*Biology*Physics. (doi:10.1016/j.ijrobp.2022.11.002 ). |
| الاتاحة: | https://eprints.soton.ac.uk/472918/ https://eprints.soton.ac.uk/472918/1/International_validation_of_the_EORTC_QLQ_ANL27.docx |
| Rights: | cc_by_nc_nd_4 |
| رقم الانضمام: | edsbas.5096413B |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |