التفاصيل البيبلوغرافية
| العنوان: |
Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe) : an analysis of paediatric survey data from 56 countries |
| المؤلفون: |
GARPEC Network, Global-PPS Network, Hsia, Yingfen, Lee, Brian R., Versporten, Ann, Saxen, H., Kekomäki, Satu, Gawrys, G. |
| المساهمون: |
Children's Hospital, HUS Children and Adolescents, Clinicum |
| بيانات النشر: |
ELSEVIER SCI IRELAND LTD |
| سنة النشر: |
2019 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
POINT PREVALENCE SURVEY, QUALITY INDICATORS, SURVEILLANCE, STEWARDSHIP, CHILDREN, Public health care science, environmental and occupational health |
| الوصف: |
Background Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed to present data on patterns of paediatric AWaRe antibiotic use that could be used for local and national stewardship interventions. Methods 1-day point prevalence survey antibiotic prescription data were combined from two independent global networks: the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children and the Global Point Prevalence Survey on Antimicrobial Consumption and Resistance networks. We included hospital inpatients aged younger than 19 years receiving at least one antibiotic on the day of the survey. The WHO AWaRe classification was used to describe overall antibiotic use as assessed by the variation between use of Access, Watch, and Reserve antibiotics, for neonates and children and for the commonest clinical indications. Findings Of the 23 572 patients included from 56 countries, 18305 were children (77.7%) and 5267 were neonates (22.3%). Access antibiotic use in children ranged from 7.8% (China) to 61.2% (Slovenia) of all antibiotic prescriptions. The use of Watch antibiotics in children was highest in Iran (77.3%) and lowest in Finland (23.0%). In neonates, Access antibiotic use was highest in Singapore (100.0%) and lowest in China (24.2%). Reserve antibiotic use was low in all countries. Major differences in clinical syndrome-specific patterns of AWaRe antibiotic use in lower respiratory tract infection and neonatal sepsis were observed between WHO regions and countries. Interpretation There is substantial global variation in the proportion of AWaRe antibiotics used in hospitalised neonates and children. The AWaRe classification could potentially be used as a simple traffic light metric of appropriate antibiotic use. Future efforts should focus on ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
GARPEC was funded by the PENTA Foundation. GARPEC-China data collection was funded by the Sanming Project of Medicine in Shenzhen (SZSM2015120330). bioMerieux provided unrestricted funding support for the Global-PPS.; GARPEC Network , Global-PPS Network , Hsia , Y , Lee , B R , Versporten , A , Saxen , H , Kekomäki , S & Gawrys , G 2019 , ' Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe) : an analysis of paediatric survey data from 56 countries ' , Lancet global health , vol. 7 , no. 7 , pp. E861-E871 . https://doi.org/10.1016/S2214-109X(19)30071-3; http://hdl.handle.net/10138/304524; 874eb4c4-e684-4059-af6a-e64bf9a189ac; 000470996500026 |
| الاتاحة: |
http://hdl.handle.net/10138/304524 |
| Rights: |
cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.508E2C24 |
| قاعدة البيانات: |
BASE |