Academic Journal
Indoleamine 2,3-Dioxygenase Is Involved in Defense against Neospora caninum in Human and Bovine Cells
| العنوان: | Indoleamine 2,3-Dioxygenase Is Involved in Defense against Neospora caninum in Human and Bovine Cells |
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| المؤلفون: | Spekker, K., Czesla, M., Ince, V., Heseler, K., Schmidt, S.K., Schares, Gereon, Daubener, W. |
| سنة النشر: | 2009 |
| المجموعة: | OpenAgrar (Senat Bundesforschung, Bundesministeriums für Ernährung und Landwirtschaft) |
| مصطلحات موضوعية: | article, Text, ddc:570, ANTIPARASITIC EFFECTOR MECHANISMS, BALB/C MICE, HOST-PARASITE RELATIONSHIP, IMMUNE-RESPONSES, INTERFERON-GAMMA, PERITONEAL-MACROPHAGES, REDUCED CEREBRAL INFECTION, TOXOPLASMA-GONDII, TRYPTOPHAN DEGRADATION, VERTICAL TRANSMISSION |
| الوصف: | Neospora caninum is an apicomplexan parasite closely related to Toxoplasma gondii. In nature this parasite is found especially in dogs and cattle, but it may also infect other livestock. The growth of N. caninum, which is an obligate intracellular parasite, is controlled mainly by the cell-mediated immune response. During infection the cytokine gamma interferon (IFN-gamma) plays a prominent role in regulating the growth of N. caninum in natural and experimental disease. The present study showed that induction of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) is responsible for the inhibition of parasite growth that is mediated by IFN-gamma-activated bovine fibroblasts and endothelial cells. This antiparasite effect could be abrogated by addition of tryptophan, as well as by the IDO-specific inhibitor 1-L-methyltryptophan. In conclusion, our data show that human and bovine cells use the same effector mechanism to control the growth of N. caninum |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Infection and immunity -- Infect. Immun.; IAI -- 1098-5522 -- 0019-9567 -- 1483247-1 -- 218698-6 -- http://iai.asm.org/ -- http://www.bibliothek.uni-regensburg.de/ezeit/?1483247 -- https://www.ncbi.nlm.nih.gov/pmc/journals/87/; https://doi.org/10.1128/IAI.00310-09; https://www.openagrar.de/receive/fimport_mods_00000837; https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00001155/SD2009229.pdf; http://iai.asm.org/content/77/10/4496.long; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747956/ |
| DOI: | 10.1128/IAI.00310-09 |
| الاتاحة: | https://doi.org/10.1128/IAI.00310-09 https://www.openagrar.de/receive/fimport_mods_00000837 https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00001155/SD2009229.pdf http://iai.asm.org/content/77/10/4496.long http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747956/ |
| Rights: | public ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.506C178C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/IAI.00310-09 |
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