Academic Journal
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
| العنوان: | Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity |
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| المؤلفون: | Cárdenas García, Casimiro, Torres-Vargas, José Antonio, Cárdenas Valdivia, Abel, Jurado, Nuria, Rodríguez-Quesada, Ana María, García-Caballero, Melissa, Martínez-Póveda, Beatriz Amparo, Medina-Torres, Miguel Ángel |
| بيانات النشر: | ELSEVIER |
| سنة النشر: | 2021 |
| المجموعة: | RIUMA - Repositorio Institucional de la Universidad de Málaga |
| مصطلحات موضوعية: | Neovascularización, Ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC–HRMS), Annona muricata, Graviola, Soursop, Angiogenesis |
| الوصف: | The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds. ; Funding for open access charge: Universidad de Málaga / CBUA. This work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA220, UMA18-FEDERJA-267 and PY20_00257 (Andalusian Government and FEDER) and funds from group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Vasculares” are initiatives from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Cárdenas, Casemiro; Torres-Vargas, José Antonio; Cárdenas Valdivia, Abel; Jurado, Nuria; Rodriguez-Quesada, Ana Maria; García-Caballero, Melissa; Martínez Poveda, Beatriz; Medina Torres, Miguel Ángel. Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity. Biomedicine & Pharmacotherapy Volume 144, December 2021, 112263. https://doi.org/10.1016/j.biopha.2021.112263; https://hdl.handle.net/10630/23975; https://doi.org/10.1016/j.biopha.2021.112263 |
| DOI: | 10.1016/j.biopha.2021.112263 |
| الاتاحة: | https://hdl.handle.net/10630/23975 https://doi.org/10.1016/j.biopha.2021.112263 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| رقم الانضمام: | edsbas.5016EAAE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.biopha.2021.112263 |
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