Academic Journal
The smoking-dyslipidaemia dyad: A potent synergistic risk for atherosclerotic coronary artery disease
| العنوان: | The smoking-dyslipidaemia dyad: A potent synergistic risk for atherosclerotic coronary artery disease |
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| المؤلفون: | Prakash, Vineet, Jaker, Sams, Burgan, Amjad, Jacques, Adam, Fluck, David, Sharma, Pankaj, Fry, Christopher H, Han, Thang S |
| المصدر: | JRSM Cardiovascular Disease ; volume 10, page 204800402098094 ; ISSN 2048-0040 2048-0040 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2021 |
| الوصف: | Background Smoking and dyslipidaemia are known individual risk factors of coronary artery disease (CAD). The present study examined the combined risk of smoking and dyslipidaemia on coronary atherosclerosis. Methods Coronary artery calcium (CAC), measured by cardiac CT, was used to assess the extent of CAD, which was related to smoking and dyslipidaemia using logistic regression, adjusted for age, sex, hypertension, BMI and family history of ischaemic heart disease. Results Seventy-one patients (46 men, 25 women: median age of 53.7yrs; IQR = 47.0–59.5) were recruited. The mean log 10 CAC score in never-smokers without dyslipidaemia (reference group) was 0.37 (SD = 0.73), while the value in those with a history of smoking was 0.44 ± 0.48 (mean difference: 0.07, 95%CI:–0.67 to 0.81, p = 0.844), dyslipidaemia was 1.07 ± 1.08 (mean difference: 0.71, 95%CI: 0.24 to 1.17, p = 0.003), and both risk factors was 1.82 ± 0.64 (mean difference: 1.45, 95%CI:0.88 to 2.02, p < 0.001). For individuals in the reference group, the proportions with none, one and multiple vessel disease were 80.6%, 16.1% and 3.2%; for those with a history of smoking or with dyslipidaemia were 50.0%, 25.0% and 25.0%; and for those with both risk factors were 8.3%, 25.0% and 66.7%. Patients with a history of both risk factors had greater adjusted risks of having one- vessel disease - OR = 14.3 (95%CI = 2.1–98.2) or multiple vessel disease: OR = 51.8 (95%CI = 4.2–609.6). Conclusions Smoking and dyslipidaemia together are associated with high coronary artery calcification and CAD, independent of other major risk factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/2048004020980945 |
| الاتاحة: | http://dx.doi.org/10.1177/2048004020980945 http://journals.sagepub.com/doi/pdf/10.1177/2048004020980945 http://journals.sagepub.com/doi/full-xml/10.1177/2048004020980945 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4FF94E4D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/2048004020980945 |
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