Book
Mineralocorticoid receptor antagonists
| العنوان: | Mineralocorticoid receptor antagonists |
|---|---|
| المؤلفون: | Rekhraj, S., Szwejkowski, Ben. R., Struthers, Allan D. |
| المساهمون: | Clark, Andrew L., Gardner, Roy S., McDonagh, Theresa A. |
| المصدر: | Oxford Textbook of Heart Failure ; page 645-650 ; ISBN 9780198766223 9780191820755 |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2022 |
| الوصف: | This chapter studies the use of aldosterone antagonists, also known as mineralocorticoid receptor antagonists (MRAs), in chronic heart failure (CHF). Overall, the results for aldosterone blockade in CHF due to left ventricular systolic dysfunction—now called heart failure with reduced ejection fraction (HFrEF)—have been very impressive with three large, undoubtedly positive results. These are the Randomized Aldactone Evaluation Study (RALES study); the Eplerenone Post-acute Myocardial Infarction Heart failure Efficacy and Survival Study (EPHESUS) study; and the Eplerenone in Mild Patients Hospitalisation and Survival Study in Heart failure (EMPHASIS-HF) study. Importantly, there are no neutral or negative studies for aldosterone blockade in HFrEF. Thus, all CHF guidelines recommend MRAs as third-line drugs after angiotensin converting enzyme inhibitors and β-blockers. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-0-19-876622-3 978-0-19-182075-5 0-19-876622-X 0-19-182075-X |
| DOI: | 10.1093/med/9780198766223.003.0052 |
| الاتاحة: | https://doi.org/10.1093/med/9780198766223.003.0052 |
| رقم الانضمام: | edsbas.4FAAE136 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780198766223 9780191820755 019876622X 019182075X |
|---|---|
| DOI: | 10.1093/med/9780198766223.003.0052 |