Academic Journal
Supplemental Breast MRI for Women with Extremely Dense Breasts:Results of the Second Screening Round of the DENSE Trial
| العنوان: | Supplemental Breast MRI for Women with Extremely Dense Breasts:Results of the Second Screening Round of the DENSE Trial |
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| المؤلفون: | Veenhuizen, Stefanie G A, de Lange, Stéphanie V, Bakker, Marije F, Pijnappel, Ruud M, Mann, Ritse M, Monninkhof, Evelyn M, Emaus, Marleen J, de Koekkoek-Doll, Petra K, Bisschops, Robertus H C, Lobbes, Marc B I, de Jong, Mathijn D F, Duvivier, Katya M, Veltman, Jeroen, Karssemeijer, Nico, de Koning, Harry J, van Diest, Paul J, Mali, Willem P T M, van den Bosch, Maurice A A J, van Gils, Carla H, Veldhuis, Wouter B, de Graaf, P |
| المصدر: | Veenhuizen , S G A , de Lange , S V , Bakker , M F , Pijnappel , R M , Mann , R M , Monninkhof , E M , Emaus , M J , de Koekkoek-Doll , P K , Bisschops , R H C , Lobbes , M B I , de Jong , M D F , Duvivier , K M , Veltman , J , Karssemeijer , N , de Koning , H J , van Diest , P J , Mali , W P T M , van den Bosch , M .... |
| سنة النشر: | 2021 |
| الوصف: | Background: In the first (prevalent) supplemental MRI screening round of the Dense Tissue and Early Breast Neoplasm Screening (DENSE) trial, a considerable number of breast cancers were found at the cost of an increased false-positive rate (FPR). In incident screening rounds, a lower cancer detection rate (CDR) is expected due to a smaller pool of prevalent cancers, and a reduced FPR, due to the availability of prior MRI examinations. Purpose: To investigate screening performance indicators of the second round (incidence round) of the DENSE trial. Materials and Methods: The DENSE trial (ClinicalTrials.gov: NCT01315015) is embedded within the Dutch population-based biennial mammography screening program for women aged 50-75 years. MRI examinations were performed between December 2011 and January 2016. Women were eligible for the second round when they again had a negative screening mammogram 2 years after their first MRI. The recall rate, biopsy rate, CDR, FPR, positive predictive values, and distributions of tumor characteristics were calculated and compared with results of the first round using 95% CIs and x 2 tests. Results: A total of 3436 women (median age, 56 years; interquartile range, 48-64 years) underwent a second MRI screening. The CDR was 5.8 per 1000 screening examinations (95% CI: 3.8, 9.0) compared with 16.5 per 1000 screening examinations (95% CI: 13.3, 20.5) in the first round. The FPR was 26.3 per 1000 screening examinations (95% CI: 21.5, 32.3) in the second round versus 79.8 per 1000 screening examinations (95% CI: 72.4, 87.9) in the first round. The positive predictive value for recall was 18% (20 of 110 participants recalled; 95% CI: 12.1, 26.4), and the positive predictive value for biopsy was 24% (20 of 84 participants who underwent biopsy; 95% CI: 16.0, 33.9), both comparable to that of the first round. All tumors in the second round were stage 0-I and node negative. Conclusion: The incremental cancer detection rate in the second round was 5.8 per 1000 screening examinations-compared with ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1148/radiol.2021203633 |
| الاتاحة: | https://research.vumc.nl/en/publications/e682060b-57cf-42f5-9041-fb36e1f057ad https://doi.org/10.1148/radiol.2021203633 http://www.scopus.com/inward/record.url?scp=85105526331&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.4F7757D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1148/radiol.2021203633 |
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