Book
Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond
| العنوان: | Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond |
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| المؤلفون: | Tsaouli G., Barbarulo A., Vacca A., Screpanti I., Felli M. P. |
| المساهمون: | Joer Reichrat, Tsaouli, G., Barbarulo, A., Vacca, A., Screpanti, I., Felli, M. P. |
| بيانات النشر: | NLM (Medline) |
| سنة النشر: | 2020 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | innate immune cell, nf-κb, notch, t-cell leukemogenesi, t-cell, animal, human, lymphocyte, nf-kappa b, receptors, cell lineage, signal transduction |
| الوصف: | Notch is a ligand-receptor interaction-triggered signaling cascade highly conserved, that influences multiple lineage decisions within the hematopoietic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1-4), and each of them plays nonredundant functions at several developmental stages. Canonical and noncanonical pathways of Notch signaling are multifaceted drivers of immune cells biology. In fact, increasing evidence highlighted Notch as an important modulator of immune responses, also in cancer microenvironment. In these contexts, multiple transduction signals, including canonical and alternative NF-κB pathways, play a relevant role. In this chapter, we will first describe the critical role of Notch and NF-κB signals in lymphoid lineages developing in thymus: natural killer T cells, thymocytes, and thymic T regulatory cells. We will address also the role played by ligand expressing cells. Given the importance of Notch/NF-κB cross talk, its role in T-cell leukemia development and progression will be discussed. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isbn/978-3-030-36421-2; info:eu-repo/semantics/altIdentifier/isbn/978-3-030-36422-9; info:eu-repo/semantics/altIdentifier/pmid/32072504; info:eu-repo/semantics/altIdentifier/wos/WOS:000539025500011; ispartofbook:Notch signaling in Embriology and Cancer; firstpage:145; lastpage:164; numberofpages:20; serie:ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY; https://hdl.handle.net/11573/1368078; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85079652326 |
| DOI: | 10.1007/978-3-030-36422-9_10 |
| الاتاحة: | https://hdl.handle.net/11573/1368078 https://doi.org/10.1007/978-3-030-36422-9_10 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.4F767234 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/978-3-030-36422-9_10 |
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