Academic Journal
Hepatic steatosis is highly prevalent across the paediatric age spectrum, including in pre‐school age children
| العنوان: | Hepatic steatosis is highly prevalent across the paediatric age spectrum, including in pre‐school age children |
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| المؤلفون: | Dhaliwal, J., Chavhan, G. B., Lurz, E., Shalabi, A., Yuen, N., Williams, B., Martincevic, I., Amirabadi, A., Wales, P. W., Lee, W., Ling, S. C., Mouzaki, M. |
| المصدر: | Alimentary Pharmacology & Therapeutics ; volume 48, issue 5, page 556-563 ; ISSN 0269-2813 1365-2036 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary Background The prevalence of non‐alcoholic fatty liver disease ( NAFLD ) in children is 8% in the general population, and 34% in the context of obesity. There is a paucity of data on the prevalence of hepatic steatosis in healthy children in Ontario. Aims To determine the prevalence of hepatic steatosis using abdominal computed tomography ( CT ) scans in a cohort of previously healthy children across the paediatric age spectrum in Ontario, Canada, and to determine any association between measures of abdominal adiposity and hepatic steatosis. Methods Retrospective review of the SickKids Trauma Database from 2004‐2015. Previously healthy children ages 1‐17 years having undergone an abdominal CT scan as a part of routine trauma assessment were included, and those with an intra‐abdominal injury excluded. Steatosis was defined as a difference between liver and spleen attenuation ≤‐25 HU . The percentage of the total area occupied by abdominal subcutaneous adipose and visceral adipose tissue was measured. Anthropometrics and baseline demographics were collected. Results A total of 503 (51% male) children with mean (± SD ) age 9.5 ± 4.5 years and weight z ‐score of 0.37 ± 1.05 were studied. Seventy‐seven (15%, 95% CI [12%‐18%]) had hepatic steatosis; no differences found between sexes or across age quartiles. The abdominal subcutaneous adipose tissue area was greater in those with hepatic steatosis compared to those without (32% [22‐42] vs 24% [17‐36], P = 0.003). The visceral adipose tissue area was significantly greater in older children ≥9.8 years with hepatic steatosis (7.7% [5.1‐10] vs 6.6% (4.9‐8.5), P = 0.04). Conclusion Hepatic steatosis was highly prevalent in previously healthy children in Ontario, including children of pre‐school age. We found an association between hepatic steatosis and abdominal subcutaneous adipose tissue, and in older children with visceral adipose tissue. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/apt.14900 |
| الاتاحة: | http://dx.doi.org/10.1111/apt.14900 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapt.14900 https://onlinelibrary.wiley.com/doi/pdf/10.1111/apt.14900 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.4F72ECE7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/apt.14900 |
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