Academic Journal
The role of structural polymorphism in driving the mechanical performance of the alzheimer's beta amyloid fibrils
| العنوان: | The role of structural polymorphism in driving the mechanical performance of the alzheimer's beta amyloid fibrils |
|---|---|
| المؤلفون: | Grasso G., Rebella M., Morbiducci U., Tuszynski J. A., Danani A., Deriu M. A. |
| المساهمون: | Grasso, G., Rebella, M., Morbiducci, U., Tuszynski, J. A., Danani, A., Deriu, M. A. |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2019 |
| المجموعة: | PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino) |
| مصطلحات موضوعية: | Alzheimer's disease, Amyloid fibril, Biomechanic, Molecular dynamic, Structural polymorphism, Young modulus |
| الوصف: | Alzheimer's Disease (AD) is related with the abnormal aggregation of amyloid β-peptides Aβ1-40 and Aβ1-42, the latter having a polymorphic character which gives rise to U- or S-shaped fibrils. Elucidating the role played by the nanoscale-material architecture on the amyloid fibril stability is a crucial breakthrough to better understand the pathological nature of amyloid structures and to support the rational design of bio-inspired materials. The computational study here presented highlights the superior mechanical behavior of the S-architecture, characterized by a Young's modulus markedly higher than the U-shaped architecture. The S-architecture showed a higher mechanical resistance to the enforced deformation along the fibril axis, consequence of a better interchain hydrogen bonds' distribution. In conclusion, this study, focusing the attention on the pivotal multiscale relationship between molecular phenomena and material properties, suggests the S-shaped Aβ1-42 species as a target of election in computational screen/design/optimization of effective aggregation modulators. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000465359000001; volume:7; issue:APR; firstpage:83; numberofpages:11; journal:FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY; http://hdl.handle.net/11583/2865992; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85064599018 |
| DOI: | 10.3389/fbioe.2019.00083 |
| الاتاحة: | http://hdl.handle.net/11583/2865992 https://doi.org/10.3389/fbioe.2019.00083 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4F60ED5B |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fbioe.2019.00083 |
|---|