التفاصيل البيبلوغرافية
| العنوان: |
Crinum jagus (J. Thomps. Dandy): Antioxidant and protective properties as a medicinal plant on toluene-induced oxidative stress damages in liver and kidney of rats |
| المؤلفون: |
Mariama, Salihu, Gaber, El-Saber Batiha, Keneth Iceland, Kasozi, George D., Zouganelis, Souty M.Z., Sharkawi, Eman, Ibrahim Ahmed, Ibe Michael, Usman, Halima, Nalugo, Juma J., Ochieng, Ibrahim, Ssengendo, Olatayo Segun, Okeniran, Theophilus, Pius, Kyobe Ronald, Kimanje, Eric Simidi, Kegoye, Ritah, Kenganzi, Fred Ssempijja |
| بيانات النشر: |
www.elsevier.com/locate/toxrep |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Anti-lipid peroxidation, Antioxidants, Catalase Crinum jagus, Glutathione superoxide dismutase, Histoprotective, Malondialdehyde, Toluene toxicity |
| الوصف: |
Crinum jagus (C. jagus; J. Thomps.) Dandy (Liliaceae) is a pantropical plant known for its medicinal values and pharmacological properties. The study assessed the protective effects and changes in oxidative stress indices due to C. jagus leaf extracts on the toluene-induced liver and kidney injuries in rats. The study was conducted on 8- week-old male Wistar rats (n = 80), weighing 243.3 ± 1.42 g. Group I, 1 ml/kg distilled water for 7 days; Group II, 4.5 ml/kg toluene once, 1 ml/kg distilled water for 7 days; Group III, 4.5 ml/kg toluene once, 500 mg/kg methanolic extract for 7 days; Group IV, 4.5 ml/kg toluene once, 500 mg/kg aqueous extract for 7 days; Group V, 500 mg/kg methanolic extract for 7 days; Group VI, 500 mg/kg aqueous extract for 7 days; Group VII, 500 mg/kg of vitamin C for 7 days; Group, VIII, 4.5 ml/kg toluene once, 500 mg/kg vitamin C for 7 days, all administrations were given by oral gavage. The phytochemical contents, absolute and relative organ weights of liver and kidneys, liver and kidney function tests, antioxidant status, as well as histological tests were analyzed using standard protocols. The tannins, flavonoids, and polyphenols were in highest concentration in both extracts, content in methanol extract (57.04 ± 1.51 mgg visible renal and hepatic histopathological findings, compared to the normal control group. In C. jagus extract test groups (III and IV), the parameters were significantly (P < 0.05) alleviated and reversed to normal/near normal compared to the negative control. The LFTs, kidney function tests, and antioxidant status were signifi- cantly (P < 0.05) more improved with the methanol extract test and standard control groups compared to the aqueous extract test group; Also, the methanol extract test group showed better histological features than the aqueous extract test and standard control groups. The methanolic extract shows better antioxidant potential due to the availability of more nonenzymatic antioxidants (tannins, flavonoids, and polyphenols). The findings ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
http://hdl.handle.net/20.500.12493/925 |
| الاتاحة: |
https://hdl.handle.net/20.500.12493/925 |
| Rights: |
Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/ |
| رقم الانضمام: |
edsbas.4F3A5C95 |
| قاعدة البيانات: |
BASE |