Academic Journal
Days of bed rest due to common cold.
| العنوان: | Days of bed rest due to common cold. |
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| المؤلفون: | Andreas Michalsen, Kim Goldenstein, Peter Kardos, Ludger Klimek, Jürgen Palm, Dajana Parganlija, Johannes Stöckl |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Pharmacology, Biotechnology, Developmental Biology, Cancer, Science Policy, Mental Health, Infectious Diseases, Virology, spearman correlation coefficient, inflammatory response treatable, faster recovering quality, exploratory clinical trial, complicates research implementation, common cold duration, 522 adults enrolled, 15 (± 2, latest treatment initiation, early cineole administration, treatment (&# 8804, cineole treatment timing, effective treatment, &# 8804, therefore explored, primary endpoint, phase iv, participants prior, mostly rated, lowest auc, average 8, adverse events |
| الوصف: | Introduction Common cold (CC) symptoms arise from an inflammatory response treatable with cineole and generally peak within two days, which complicates research implementation. We therefore explored the benefits of early cineole administration with enrolment of participants prior to CC onset. Methods Out of 522 adults enrolled in our phase IV, open-label, non-randomized, exploratory clinical trial (EudraCT No. 2020-000860-51), 329 developed a CC and used 200 mg cineole (Soledum ® , CNL-1976) t.i.d. for max. 15 (± 2) days. Primary endpoint was burden of disease based on the Wisconsin Upper Respiratory Symptom Survey (WURSS-11). Results Comparing three strata based on time to treatment (≤ 12 h, > 12 to ≤ 24 h and > 24 h), earliest treatment resulted in lowest AUC-WURSS (Spearman correlation coefficient of 0.36) and reduced the overall burden of disease by 38% (p < 0.0001). Earlier and lower symptom severity peak resulted, with shorter time to remission (average 8.9 vs. 10.7 days with latest treatment initiation, p < 0.05), and higher and faster recovering quality of life (p < 0.05). Tolerability was mostly rated as “very good”, with adverse events of suspected causal relationship reported in 4.3% of participants. Conclusions Early intervention shows clinical benefits relevant for the effective treatment of CC with cineole. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Days_of_bed_rest_due_to_common_cold_/25022678 |
| DOI: | 10.1371/journal.pone.0296482.s012 |
| الاتاحة: | https://doi.org/10.1371/journal.pone.0296482.s012 https://figshare.com/articles/journal_contribution/Days_of_bed_rest_due_to_common_cold_/25022678 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.4F2377EC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0296482.s012 |
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