Academic Journal
Raman spectroscopy and its plasmon‐enhanced counterparts: A toolbox to probe protein dynamics and aggregation
| العنوان: | Raman spectroscopy and its plasmon‐enhanced counterparts: A toolbox to probe protein dynamics and aggregation |
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| المؤلفون: | Dhillon, Ashish Kumar, Sharma, Arti, Yadav, Vikas, Singh, Ruchi, Ahuja, Tripti, Barman, Sanmitra, Siddhanta, Soumik |
| المصدر: | WIREs Nanomedicine and Nanobiotechnology ; volume 16, issue 1 ; ISSN 1939-5116 1939-0041 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Protein unfolding and aggregation are often correlated with numerous diseases such as Alzheimer's, Parkinson's, Huntington's, and other debilitating neurological disorders. Such adverse events consist of a plethora of competing mechanisms, particularly interactions that control the stability and cooperativity of the process. However, it remains challenging to probe the molecular mechanism of protein dynamics such as aggregation, and monitor them in real‐time under physiological conditions. Recently, Raman spectroscopy and its plasmon‐enhanced counterparts, such as surface‐enhanced Raman spectroscopy (SERS) and tip‐enhanced Raman spectroscopy (TERS), have emerged as sensitive analytical tools that have the potential to perform molecular studies of functional groups and are showing significant promise in probing events related to protein aggregation. We summarize the fundamental working principles of Raman, SERS, and TERS as nondestructive, easy‐to‐perform, and fast tools for probing protein dynamics and aggregation. Finally, we highlight the utility of these techniques for the analysis of vibrational spectra of aggregation of proteins from various sources such as tissues, pathogens, food, biopharmaceuticals, and lastly, biological fouling to retrieve precise chemical information, which can be potentially translated to practical applications and point‐of‐care (PoC) devices. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > Diagnostic Nanodevices Nanotechnology Approaches to Biology > Nanoscale Systems in Biology |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/wnan.1917 |
| الاتاحة: | http://dx.doi.org/10.1002/wnan.1917 https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wnan.1917 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.4EE7EA68 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/wnan.1917 |
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