Academic Journal
HFA-ICOS cardiovascular toxicity risk score validation in CARDIOTOX registry
| العنوان: | HFA-ICOS cardiovascular toxicity risk score validation in CARDIOTOX registry |
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| المؤلفون: | Rivero Santana, B, Caro Codon, J, Juarez Olmos, V, Martinez Monzonis, A, Zatarain-Nicolas, E, Moliner, P, Cadenas Chamorro, R, Severo Sanchez, A, Valbuena Lopez, S, Zamora Aunon, P, Gomez Prieto, P, Gonzalez Juanatey, J R, Lopez-Sendon, J, Lopez De Sa, E, Lopez-Fernandez, T |
| المصدر: | European Heart Journal ; volume 43, issue Supplement_2 ; ISSN 0195-668X 1522-9645 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | Background Cancer therapy-related cardiovascular toxicity (CTox) is a growing medical problem and baseline cardiovascular (CV) risk assessment is recommended in all patients scheduled to receive potentially cardiotoxic cancer therapy. Based on literature review, the Heart Failure Association (HFA) Cardio-Oncology working group and the International Cardio-Oncology Society (ICOS) proposed a risk score to predict CTox but, it has not been validated. Purpose To validate the HFA-ICOS anthracycline risk assessment score in the CARDIOTOX registry cohort (NCT02039622). Methods The CARDIOTOX registry is a prospective multicenter study aiming at identifying factors related with CTox and assessing the utility of clinical, biochemical, and echo parameters for the early detection of CV disease during and after cancer therapy. A total of 1324 adult patients were prospectively included from April 2012 to October 2017. Data was collected at baseline, 3 weeks and 3, 6, 12, 18 and 24 months after initiation of treatment. Clinical follow-up was extended until January 2020. All patients receiving anthracycline chemotherapy were stratified according to HFA-ICOS risk score and Kaplan-Meier survival curves were analyzed to estimate the risk of all-cause mortality and anthracycline chemotherapy-related CV complications defined by HFA-ICOS risk score (left ventricular dysfunction (LVD), heart failure (HF) and arrhythmias). Results A total of 1066 patients were included in the analysis. Baseline characteristics are summarized in table 1. 571 patients (53.6%) meet low, 333 (31.2%) medium, 152 (14.3%) high and 10 (0.9%) very-high HFA-ICOS CTox risk criteria. 197 patients (18.4%) died of any cause during follow-up. CV death occurred in 4 patients (2%), all caused by HF. Any degree of CTox was identified in 519 (48.7%) patients during the 110 months follow-up (73 (6.8%) developed clinical HF/HF hospitalization, 29 (2.7%) asymptomatic LVEF <50%; 27 (2.5%) clinically relevant arrhythmias and 390 (36.6%) an asymptomatic ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/eurheartj/ehac544.2591 |
| الاتاحة: | https://doi.org/10.1093/eurheartj/ehac544.2591 https://academic.oup.com/eurheartj/article-pdf/43/Supplement_2/ehac544.2591/46370319/ehac544.2591.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.4E9EE047 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurheartj/ehac544.2591 |
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