Academic Journal
SDS-PAGE JASMINA TONIC RIBARSKA*
| العنوان: | SDS-PAGE JASMINA TONIC RIBARSKA* |
|---|---|
| المؤلفون: | Suzana Trajkovic Jolevska, Ana Poceva Panovska |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://public.carnet.hr/acphee/19908.pdf. |
| سنة النشر: | 2008 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | lenograstim, aggregate formation |
| الوصف: | With the development of recombinant DNA-technology, the DNA-derived drugs represent a new therapeutic concept for human diseases (1). Two forms of recombinant human granulocyte colony-stimulating factor (rHuG-CSF) are currently commercially available for medical treatment, non-glycosylated protein (filgrastim) and glycosylated protein lenograstim, with molecular mass of 19.6 kDa (2). Glycosylation has been repor-ted to confer many advantages over non-glycosylation, including improvement of phy-sical stability (3–6) and higher biological and pharmacological potency (5, 7, 8). A common phenomenon of protein instability and a dominant degradation path-way for therapeutic proteins is formation of aggregates (9). It is encountered routinely during refolding, purification, sterilization, shipping and storage processes (10, 11). Ag- |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.565.4318; http://public.carnet.hr/acphee/19908.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.565.4318 http://public.carnet.hr/acphee/19908.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.4E5DD276 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |