Academic Journal
Microbial-Driven Synthesis and Hydrolysis of Neohesperidin Dihydrochalcone: Biotransformation Process and Feasibility Investigation
| العنوان: | Microbial-Driven Synthesis and Hydrolysis of Neohesperidin Dihydrochalcone: Biotransformation Process and Feasibility Investigation |
|---|---|
| المؤلفون: | Yucong Zou, Xiaofeng Li, Xuan Xin, Haixia Xu, Guanglei Zhao |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Microbiology, Genetics, Biotechnology, Ecology, Immunology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, citrus processing wastes, traditional chemical hydrogenation, hydrolysis products could, effective catalysts compared, cell catalytic hydrolysis, cell hydrolysis, mediated hydrogenation, value compounds, step biosynthesis, reaction system, potential sweeteners, pot two, new route, neohesperidin dihydrochalcone, hesperetin dihydrochalcone, feasibility investigation, enhanced safety, biotransformation process, also offers, also designed, >- glucoside |
| الوصف: | A novel yeast-mediated hydrogenation was developed for the synthesis of neohesperidin dihydrochalcone (NHDC) in high yields (over 83%). Moreover, whole-cell catalytic hydrolysis was also designed to hydrolyze NHDC into potential sweeteners, hesperetin dihydrochalcone-7- O -glucoside (HDC-G) and hesperetin dihydrochalcone (HDC). The biohydrogenation was further combined with whole-cell hydrolysis to achieve a one-pot two-step biosynthesis, utilizing yeast to hydrogenate CC in the structure, while Aspergillus niger cells hydrolyze glycosides. The conversion of NHDC and the proportion of hydrolysis products could be controlled by adjusting the catalysts, the components of the reaction system, and the addition of glucose. Furthermore, yeast-mediated biotransformation demonstrated superior reaction stability and enhanced safety and employed more cost-effective catalysts compared to the traditional chemical hydrogenation of NHDC synthesis. This research not only provides a new route for NHDC production but also offers a safe and flexible one-pot cascade biosynthetic platform for the production of high-value compounds from citrus processing wastes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Microbial-Driven_Synthesis_and_Hydrolysis_of_Neohesperidin_Dihydrochalcone_Biotransformation_Process_and_Feasibility_Investigation/25150803 |
| DOI: | 10.1021/acs.jafc.3c08339.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.jafc.3c08339.s001 https://figshare.com/articles/journal_contribution/Microbial-Driven_Synthesis_and_Hydrolysis_of_Neohesperidin_Dihydrochalcone_Biotransformation_Process_and_Feasibility_Investigation/25150803 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.4E5BD297 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jafc.3c08339.s001 |
|---|