Image
Heat map representation (row Z-score) of the general thermal stability of Li FS-B soluble protein cell extracts.
| العنوان: | Heat map representation (row Z-score) of the general thermal stability of Li FS-B soluble protein cell extracts. |
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| المؤلفون: | Lorena Bernardo, Ana Victoria Ibarra-Meneses, Noelie Douanne, Audrey Corbeil, Jose Carlos Solana, Francis Beaudry, Eugenia Carrillo, Javier Moreno, Christopher Fernandez-Prada |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Medicine, Pharmacology, Evolutionary Biology, Ecology, Immunology, Cancer, Infectious Diseases, Virology, reactive oxygen species, displaying high levels, depressed immune system, alarmingly growing levels, ones receiving methotrexate, clinical strains (<, effective treatment coupled, reference strain (<, dog later relapsing, undermine antileishmanial treatment, refusing antileishmanial drugs, leishmania infantum <, treated vl dogs, leishmania <, infantum <, antileishmanial drugs, methotrexate cross, circulating strains, li <, l <, wide range, results show |
| الوصف: | Normalized protein abundance of Li FS-B proteins for which full melting curves were acquired in the absence ( A ) or in the presence ( B ) of 100 μM Sb (42 proteins) and in the absence ( C ) or in the presence ( D ) of 100 μM MTX (55 proteins). Color range depicts the relative protein abundance of the soluble fractions at different temperatures. Heat maps were generated through the Heat mapper webserver ( www.heatmapper.ca/expression ) using its protein expression plugin with average linkage as clustering method applied to rows and Euclidean as distance measurement method. Of note, within the two field strains, 20 proteins were identified as shared following exposure to Sb. These shared proteins encompass ribosomal proteins, elongation factors, and heat shock proteins. Additionally, 14 proteins were recognized as common to both strains subsequent to their interaction with MTX, highlighting a prevalence of ribosomal proteins and those associated with the parasite’s cellular respiration. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Heat_map_representation_row_Z-score_of_the_general_thermal_stability_of_i_Li_i_FS-B_soluble_protein_cell_extracts_/25320348 |
| DOI: | 10.1371/journal.pntd.0012015.g005 |
| الاتاحة: | https://doi.org/10.1371/journal.pntd.0012015.g005 https://figshare.com/articles/figure/Heat_map_representation_row_Z-score_of_the_general_thermal_stability_of_i_Li_i_FS-B_soluble_protein_cell_extracts_/25320348 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.4E585CE1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pntd.0012015.g005 |
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