Academic Journal
Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy
| العنوان: | Clot-Inducing Minerals Versus Plasma Protein Dressing for Topical Treatment of External Bleeding in the Presence of Coagulopathy |
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| المؤلفون: | Kheirabadi, Bijan S, Mace, James E, Terrazas, Irasema B, Fedyk, Chriselda G, Valdez, Krystal K, MacPhee, Martin J, Beall, Dawson, Estep, J S, Dubick, Michael A, Blackbourne, Lorne H |
| المساهمون: | ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX |
| المصدر: | DTIC |
| سنة النشر: | 2010 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Anatomy and Physiology, Medicine and Medical Research, Medical Facilities, Equipment and Supplies, Military Forces and Organizations, BLOOD COAGULATION, DRESSINGS, HEMORRHAGE, ANGIOGRAPHY, BLOOD CELLS, BLOOD PLASMA, BLOOD PRESSURE, CASUALTIES, COMPUTERIZED TOMOGRAPHY, FEMORAL ARTERIES, FIBRIN, FIBRINOGEN, FLUIDS, HISTOLOGY, HYPOTHERMIA, MILITARY MEDICINE, RESUSCITATION, SURGERY, SWINE, TISSUES(BIOLOGY), WARFARE, WOUNDS AND INJURIES, COMBAT GAUZE, WOUNDSTAT, FIBRINOGEN/FIBRIN DRESSINGS |
| الوصف: | Background: Previous studies identified WoundStat (WS, smectite) and Combat Gauze (CG, kaolin-coated gauze) as the most effective available agents for controlling arterial bleeding with potential utility in casualty care. Tissue sealant properties of WS suggested its potential advantage over clot-promoting CG for treating coagulopathic bleeding. This study compared the efficacy of CG and WS with a fibrinogen-based (FAST) dressing to control bleeding in coagulopathic animals. Methods: Coagulopathy was induced in pigs (n = 55, 35 kg) by approximately 50% isovolemic hemodilution and hypothermia (core temperature, 33 Degrees C + or - 0.5 Degrees C). A 6-mm arteriotomy was made in the femoral artery and free bleeding allowed for 30 seconds. A test agent (n 13-15 per group) or control product (gauze, GZ, n = 12) was applied to the wounds and compressed with a Kerlix gauze for 2 minutes. Fluid resuscitation was given, titrated to a mean arterial pressure of 65 mm Hg. Animals were observed for 180 minutes or until death. Angiography using the computed tomography method was performed on survivors, and local tissues were collected for histology. ; Published in the Journal of Trauma, v69 n5 p1062-1073, November 2010. Presented at the 23rd Annual Meeting of the Eastern Association for the Surgery of Trauma, held in Phoenix, AZ, 19-23 January 2010. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA630324 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA630324 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA630324 |
| Rights: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.4E49325C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |