التفاصيل البيبلوغرافية
| العنوان: |
Anti-cN1A antibodies are associated with more severe dysphagia in sporadic inclusion body myositis |
| المؤلفون: |
Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M |
| المصدر: |
Cells, May 2021 |
| بيانات النشر: |
MDPI |
| سنة النشر: |
2021 |
| المجموعة: |
Newcastle University Library ePrints Service |
| الوصف: |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a com-mercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/289731; https://eprints.ncl.ac.uk/fulltext.aspx?url=289731/F1C8686C-319E-4650-9AA1-FBC8DA44BB58.pdf&pub_id=289731 |
| الاتاحة: |
https://eprints.ncl.ac.uk/289731 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.4D679FFE |
| قاعدة البيانات: |
BASE |