التفاصيل البيبلوغرافية
| العنوان: |
Bio-Inspired Molecularly Imprinted Polymer Electrochemical Sensor for Cortisol Detection Based on O-Phenylenediamine Optimization |
| المؤلفون: |
Minwoo Kim, Daeil Park, Joohyung Park, Jinsung Park |
| المصدر: |
Biomimetics; Volume 8; Issue 3; Pages: 282 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
biomimic, cortisol, molecularly imprinted polymer, O-PD optimization, electrochemistry |
| الوصف: |
This paper presents a comprehensive investigation of the various parameters involved in the fabrication of a molecularly imprinted polymer (MIP) sensor for the detection of cortisol. Parameters such as monomer concentration, electropolymerization cycles, pH, monomer–template ratio, template removal technique, and rebinding time were optimized to establish a more consistent and effective method for the fabrication of MIP sensors. Under the optimized conditions, the MIP sensor demonstrated a proportional decrease in differential pulse voltammetry peak currents with increasing cortisol concentration in the range of 0.1 to 100 nM. The sensor exhibited excellent sensitivity, with a limit of detection of 0.036 nM. Selectivity experiments using a non-imprinted polymer sensor confirmed the specific binding affinity of the MIP sensor for cortisol, distinguishing it from other steroid hormones. This study provides crucial insights into the development of a reliable and sensitive strategy for cortisol detection using O-PD-based MIPs. These findings laid the foundation for further advancements in MIP research. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Biomimetic Design, Constructions and Devices; https://dx.doi.org/10.3390/biomimetics8030282 |
| DOI: |
10.3390/biomimetics8030282 |
| الاتاحة: |
https://doi.org/10.3390/biomimetics8030282 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.4D4F4F79 |
| قاعدة البيانات: |
BASE |