التفاصيل البيبلوغرافية
| العنوان: |
Reduction in Rumen Tetracycline-Insensitive Bacteria during a Grain Challenge Using the Isoflavone Biochanin A |
| المؤلفون: |
Michael D. Flythe, Brittany E. Davis, Isabelle A. Kagan |
| المصدر: |
Veterinary Sciences; Volume 10; Issue 4; Pages: 273 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
antibiotic growth promoter, antibiotic-resistance, antimicrobial-resistance, functional feed, forage, legume, phytochemical, plant secondary metabolite |
| جغرافية الموضوع: |
agris |
| الوصف: |
The isoflavone biochanin A was previously shown to promote weight gain in growing steers by selectively inhibiting rumen bacteria-like growth-promoting feed antibiotics. The hypothesis that biochanin A inhibited the action of drug efflux pumps was tested by enumerating tetracycline-insensitive bacteria from steers in a subacute rumen acidosis (SARA) challenge. Steers (n = 3/group) treatment groups were forage only, SARA control, SARA with monensin (0.2 g d−1), and SARA with biochanin A (6.0 g d−1). As the steers were stepped up from the forage-only basal diet to 70% cracked corn, the number of rumen bacteria enumerated on two tetracycline-containing media types (nutrient glucose agar and tetracycline, and bile esculin azide and tetracycline) increased (p < 0.05) from as little as 1.7(105) to as great as 6.7(106) cfu mL−1 on the nutrient glucose agar in the SARA and monensin control groups. The biochanin A group maintained the same number of tetracycline-insensitive bacteria as the forage-only controls (p > 0.05). The effects were similar to the more selective media type, but the differences were smaller. These results support the hypothesis that biochanin A inhibits the activity of drug efflux pumps in vivo. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Veterinary Microbiology, Parasitology and Immunology; https://dx.doi.org/10.3390/vetsci10040273 |
| DOI: |
10.3390/vetsci10040273 |
| الاتاحة: |
https://doi.org/10.3390/vetsci10040273 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.4D496A2A |
| قاعدة البيانات: |
BASE |