التفاصيل البيبلوغرافية
| العنوان: |
Vulnerability in regionally ischemic human heart. Effect of the extracellular potassium concentration |
| المؤلفون: |
Rodriguez-Matas, Jose F, Mena-Tobar, Andres, Ferrero, Jose M, Migliavacca, Francesco |
| سنة النشر: |
2024 |
| المجموعة: |
Zenodo |
| الوصف: |
Ventricular tachycardia and ventricular fibrillation are two types of cardiac arrhythmias that usuallyoccur during acute ischemia and frequently lead to sudden death. Pro-arrhythmic mechanisms relatedto acute ischemia have been extensively investigated, although often in animal models rather than inhuman. In this work, we investigate how hyperkalemia affects the vulnerable window to reentry and thereentry patterns in the heterogeneous substrate caused by acute regional ischemia using an anatomicallyand biophysically detailed human biventricular model. The ischemic region was located in the inferolat-eral and posterior side of the left ventricle, mimicking the occlusion of the circumflex artery, and includesa wash-out zone not affected by ischemia located in the endocardium. Realistic heterogeneity and fiberanisotropy have been considered in the model. An electrophysiologically detailed human action potentialmodel has been modified to simulate ischemic conditions. The model predicts the generation of sustainedreentrant activity in the form of single and double circuits around an area of block within the ischemiczone for K+concentrations below 9 mM, with the reentrant activity corresponding to ventricular tachy-cardia in all cases. Our results also suggest that the wash-out zone is a potential pro-arrhythmic factorthat favors sustained ventricular tachycardia. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| Relation: |
https://doi.org/10.1016/j.jocs.2017.11.009; oai:zenodo.org:10640296 |
| DOI: |
10.1016/j.jocs.2017.11.009 |
| الاتاحة: |
https://doi.org/10.1016/j.jocs.2017.11.009 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.4D20009B |
| قاعدة البيانات: |
BASE |