Academic Journal
Lung diffusing capacity for nitric oxide in space: microgravity gas density interactions
| العنوان: | Lung diffusing capacity for nitric oxide in space: microgravity gas density interactions |
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| المؤلفون: | Karlsson, Lars L., Van Muylem, Alain, Linnarsson, Dag |
| المساهمون: | Swedish National Space Agency |
| المصدر: | Frontiers in Physiology ; volume 14 ; ISSN 1664-042X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2023 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Introduction: During manned space exploration lung health is threatened by toxic planetary dust and radiation. Thus, tests such as lung diffusing capacity (DL) are likely be used in planetary habitats to monitor lung health. During a DL maneuver the rate of uptake of an inspired blood-soluble gas such as nitric oxide (NO) is determined (DL NO ). The aim of this study was to investigate the influence of altered gravity and reduced atmospheric pressure on the test results, since the atmospheric pressure in a habitat on the moon or on Mars is planned to be lower than on Earth. Changes of gravity are known to alter the blood filling of the lungs which in turn may modify the rate of gas uptake into the blood, and changes of atmospheric pressure may alter the speed of gas transport in the gas phase. Methods: DL NO was determined in 11 subjects on the ground and in microgravity on the International Space Station. Experiments were performed at both normal (1.0 atm absolute, ata) and reduced (0.7 ata) atmospheric pressures. Results: On the ground, DL NO did not differ between pressures, but in microgravity DL NO was increased by 9.8% (9.5) (mean [SD]) and 18.3% (15.8) at 1.0 and 0.7 ata respectively, compared to normal gravity, 1.0 ata. There was a significant interaction between pressure and gravity ( p = 0.0135). Discussion: Estimates of the membrane (Dm NO ) and gas phase (Dg NO ) components of DL NO suggested that at normal gravity a reduced pressure led to opposing effects in convective and diffusive transport in the gas phase, with no net effect of pressure. In contrast, a DL NO increase with reduced pressure at microgravity is compatible with a substantial increase of Dm NO partially offset by reduced Dg NO , the latter being compatible with interstitial edema. In microgravity therefore, Dm NO would be proportionally underestimated from DL NO . We also conclude that normal values for DL in anticipation of planetary exploration should be determined not only on the ground but also at the gravity and pressure ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fphys.2023.1161062 |
| DOI: | 10.3389/fphys.2023.1161062/full |
| الاتاحة: | http://dx.doi.org/10.3389/fphys.2023.1161062 https://www.frontiersin.org/articles/10.3389/fphys.2023.1161062/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4D093F62 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fphys.2023.1161062 |
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