Academic Journal
Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study
| العنوان: | Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study |
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| المؤلفون: | Akpınar, Seval, Tekgündüz, Emre, Erkurt, Mehmet Ali, Esen, Ramazan, Karakuş, Volkan |
| المساهمون: | MÜ, Tıp Fakültesi, Eğitim ve Araştırma Hastanesiü, orcid:0000-0001-9178-2850, Karakuş, Volkan |
| بيانات النشر: | Elsevier Ltd |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Thrombotic microangiopathy, Hematopoietic cell transplantation, Thrombotic thrombocytopenic purpura, Hemolytic uremic syndrome |
| الوصف: | Thrombotic microangiopathy(TMA) is a pathological diagnosis characterized by abnormalities of small vessels leading to microvascular thrombosis of arterioles and capillaries. The current prospective, non-interventional, multicenter (n:18) study aimed to define distribution of different TMA forms in adult Turkish patients who were referred for therapeutic plasma exchange (TPE) for a presumptive diagnosis of TMA. Patients with serum ADAMTS13 activity [removed]10 %, normal renal function and no secondary TMA were treated as unclassified TMA. The study included a total of 97 patients (female: 60; male: 30) with a median age of 48 (18−74). Detailed evaluation at 1 month after hospital admission revealed aTTP, secondary TMA, infection/complement-associated hemolytic uremic syndrome and unclassified TMA in 32 (33 %), 33 (34 %), 26 (27 %) and 6 (6%) patients respectively. As subclassification of various TMAs will dictate specific therapy, proper diagnosis in a timely manner is of utmost clinical significance |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 14730502 |
| Relation: | Transfusion and Apheresis Science; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; [1]Akpınar S, Tekgunduz E, Erkurt MA, Esen R, Yılmaz M, Karakus V, et al. Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA): The Turkish hematology research and education group (ThREG)-TMA02 study. Transfusion and Apheresis Science 2021:103312. doi:10.1016/j.transci.2021.103312.; https://doi.org/10.1016/j.transci.2021.103312; https://hdl.handle.net/20.500.12809/9666 |
| DOI: | 10.1016/j.transci.2021.103312 |
| الاتاحة: | https://hdl.handle.net/20.500.12809/9666 https://doi.org/10.1016/j.transci.2021.103312 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.4CF4263C |
| قاعدة البيانات: | BASE |
| تدمد: | 14730502 |
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| DOI: | 10.1016/j.transci.2021.103312 |