Academic Journal
Histone H1: Lessons from Drosophila
| العنوان: | Histone H1: Lessons from Drosophila |
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| المؤلفون: | Bayona-Feliu, Aleix, Casas-Lamesa, Anna, Carbonell, Albert, Climent-Cantó, Paula, Tatarski, Milos, Pérez-Montero, Salvador, Azorín, Ferran, Bernués, Jordi |
| المساهمون: | Generalitat de Catalunya, Ministerio de Economía y Competitividad (España) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | Eukaryotic genomes are structured in the formof chromatin with the help of a set of five small basic proteins, the histones. Four of them are highly conserved through evolution, form the basic unit of the chromatin, the nucleosome, and have been intensively studied and are well characterized. The fifth histone, histone H1, adds to this basic structure through its interaction at the entry/exit site of DNA in the nucleosomeandmakes an essential contribution to the higher order folding of the chromatin fiber. Histone H1 is the less conserved histone and the less known of them. Though for long time considered as a general repressor of gene expression, recent studies in Drosophila have rejected this view and have contributed to uncover important functions on genome stability and development. Here we present some of the most recent data obtained in the Drosophila model system and discuss how the lessons learnt in these studies compare and could be applied to all other eukaryotes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan. ; Work in the authors' laboratory is supported by grants from MINECO (BFU2012-30724) and the Generalitat de Catalunya (SGR2014-204) ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1876-4320 |
| Relation: | http://dx.doi.org/10.1016/j.bbagrm.2015.09.001; Sí; Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1859(3): 526-532 (2016); http://hdl.handle.net/10261/133908; http://dx.doi.org/10.13039/501100002809; http://dx.doi.org/10.13039/501100003329 |
| DOI: | 10.1016/j.bbagrm.2015.09.001 |
| DOI: | 10.13039/501100002809 |
| DOI: | 10.13039/501100003329 |
| الاتاحة: | http://hdl.handle.net/10261/133908 https://doi.org/10.1016/j.bbagrm.2015.09.001 https://doi.org/10.13039/501100002809 https://doi.org/10.13039/501100003329 |
| Rights: | none |
| رقم الانضمام: | edsbas.4C3B09F8 |
| قاعدة البيانات: | BASE |
| تدمد: | 18764320 |
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| DOI: | 10.1016/j.bbagrm.2015.09.001 |