التفاصيل البيبلوغرافية
| العنوان: |
Pt(II)‐Phenanthroline‐Ln(III)‐DOTA d–f Hybrids as Small‐Molecule Theranostics |
| المؤلفون: |
Brito, Beatriz, Price, Thomas W., Bañobre‐López, Manuel, Gallo, Juan, Stasiuk, Graeme J. |
| المساهمون: |
University of Hull, Engineering and Physical Sciences Research Council |
| المصدر: |
European Journal of Inorganic Chemistry ; volume 27, issue 17 ; ISSN 1434-1948 1099-0682 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
1,10‐Phenanthroline d‐ or f‐ metal complexes can be utilised in biomedical applications such as imaging or therapeutics. Herein, we designed bimetallic d ‐block metal‐phenanthroline f ‐block metal‐1,4,7,10‐tetraazacyclododecane‐1,4,7,1,0‐tetraacetic acid (DOTA) conjugates as theranostic agents to simultaneously achieve both of these applications. Luminescence studies show the 1,10‐phenanthroline‐Eu(III)‐DOTA complexes displayed an off/on/off pH‐dependent switch, demonstrating their potential as pH‐responsive lanthanide luminescence probes. Relaxometry studies showed that the 1,10‐phenanthroline‐Gd(III)‐DOTA complexes present a r 1 of 5.15±0.05 mM −1 s −1 and could thus be used as magnetic resonance (MR) contrast agents. Complexation of Pt(II) by the 1,10‐phenanthroline moiety resulted in quenching of the Eu(III) luminescence, but an enhancement of the Gd(III) relaxivity ( r 1 =7.53±0.69 mM −1 s −1 ). Cell viability studies of the d–f hybrids in a cancer cell line showed the potential of these complexes as anticancer agents, as the IC 50 for the Pt(II)/Gd(III) complex (IC 50 =24.9 μM) was lower than that of cisplatin (IC 50 =31.6 μM). As such, Pt(II)‐1,10‐phenanthroline‐Gd(III)‐DOTA complexes are promising theranostic agents for cancer therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/ejic.202400063 |
| الاتاحة: |
http://dx.doi.org/10.1002/ejic.202400063 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.4C1B7DC4 |
| قاعدة البيانات: |
BASE |