Academic Journal
Exclusion Criteria and Generalizability in Bipolar Disorder Treatment Trials
| العنوان: | Exclusion Criteria and Generalizability in Bipolar Disorder Treatment Trials |
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| المؤلفون: | Wong, Jessie J., Jones, Nev, Timko, Christine, Humphreys, Keith |
| المصدر: | Mental Health Law & Policy Faculty Publications |
| بيانات النشر: | Digital Commons @ University of South Florida |
| سنة النشر: | 2018 |
| المجموعة: | University of South Florida St. Petersburg: Digital USFSP |
| مصطلحات موضوعية: | Generalizability, Bipolar treatment, Research design, External validity, Translation, Health Law and Policy, Mental Disorders |
| الوصف: | Objective: The current paper reviews the English-language research on exclusion criteria in bipolar disorder treatment trials and discusses how study samples compare to the general bipolar patient population. Methods: & Results: Across 8 identified studies of exclusion criteria and their impact, between 55% and 96% of people with bipolar disorder would be excluded from treatment research. The number of exclusion criteria varies across bipolar disorder treatment research, with one study estimate of a median of 7 criteria used across studies. The criteria that excluded the greatest number of potential participants were comorbid substance use disorder, suicidal risk, and comorbid medical conditions. Both studies that compared treatment responses among participants who met and did not meet exclusion criteria found no statistically significant differences. Conclusions: Most potential participants are excluded from outcome research, which creates challenges for recruitment and limits generalizability of study findings. Common exclusionary practices lead to unrepresentative samples that limit generalizability and reduce the confidence of clinicians that findings can be translated to front-line practice with bipolar disorder patients. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://digitalcommons.usf.edu/mhlp_facpub/937; https://digitalcommons.usf.edu/context/mhlp_facpub/article/1945/viewcontent/1_s2.0_S2451865417301503_main.pdf |
| DOI: | 10.1016/j.conctc.2018.01.009 |
| الاتاحة: | https://digitalcommons.usf.edu/mhlp_facpub/937 https://doi.org/10.1016/j.conctc.2018.01.009 https://digitalcommons.usf.edu/context/mhlp_facpub/article/1945/viewcontent/1_s2.0_S2451865417301503_main.pdf |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4BB4C09A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.conctc.2018.01.009 |
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