التفاصيل البيبلوغرافية
| العنوان: |
Video_1_Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function.avi |
| المؤلفون: |
Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tetsuya Hirabayashi, Kojiro Mukai, Kohji Kasahara, Keiyo Takubo, Nobuhito Goda, Koichi Honke, Tomohiko Taguchi, Hiroyuki Sorimachi, Noriko Toyama-Sorimachi |
| سنة النشر: |
2024 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, inhibitory receptor, Ly49, MHC class I, cis interaction, sphingolipids, 2 phagocytosis, lipid raft, macrophage |
| الوصف: |
Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role of this interaction is uncertain. Ly49Q, an atypical Ly49 receptor expressed in non-NK cells, binds MHC-I in cis and mediates chemotaxis of neutrophils and type I interferon production by plasmacytoid dendritic cells. We identified a lipid-binding motif in the juxtamembrane region of Ly49Q and found that Ly49Q organized functional membrane domains comprising sphingolipids via sulfatide binding. Ly49Q recruited actin-remodeling molecules to an immunoreceptor tyrosine-based inhibitory motif, which enabled the sphingolipid-enriched membrane domain to mediate complicated actin remodeling at the lamellipodia and phagosome membranes during phagocytosis. Thus, Ly49Q facilitates integrative regulation of proteins and lipid species to construct a cell type-specific membrane platform. Other Ly49 members possess lipid binding motifs; therefore, membrane platform organization may be a primary role of some NK cell receptors. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/media/Video_1_Collaboration_between_a_cis-interacting_natural_killer_cell_receptor_and_membrane_sphingolipid_is_critical_for_the_phagocyte_function_avi/25679109 |
| DOI: |
10.3389/fimmu.2024.1401294.s004 |
| الاتاحة: |
https://doi.org/10.3389/fimmu.2024.1401294.s004
https://figshare.com/articles/media/Video_1_Collaboration_between_a_cis-interacting_natural_killer_cell_receptor_and_membrane_sphingolipid_is_critical_for_the_phagocyte_function_avi/25679109 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.4B6297C4 |
| قاعدة البيانات: |
BASE |