Academic Journal
Perirenal fat thickness as a superior obesity-related marker of subclinical carotid atherosclerosis in type 2 diabetes mellitus
| العنوان: | Perirenal fat thickness as a superior obesity-related marker of subclinical carotid atherosclerosis in type 2 diabetes mellitus |
|---|---|
| المؤلفون: | Xiu Li Guo, Jian Wen Wang, Mei Tu, Wei Wang |
| المصدر: | Frontiers in Endocrinology, Vol 14 (2023) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | obesity, perirenal fat thickness, sub-clinical carotid atherosclerosis, carotid intima-to-media thickness, type 2 diabetes mellitus, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | ObjectiveEmerging evidence highlighted that perirenal adipose tissue might regulate the cardiovascular and metabolism system through several pathways. This study aimed to assess the association between perirenal fat thickness (PrFT) and subclinical carotid atherosclerosis (SCCA) in type 2 diabetes mellitus (T2DM).MethodA total of 670 participants with complete data were included in this study. The trained reviewer collected demographic and anthropometric information. Laboratory assessments were determined by standard methods. PrFT and SCCA were evaluated by computed tomography and ultrasound. Binomial logistic regression analysis was conducted to assess the association between PrFT and SCCA. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the identifying value of PrFT for SCCA.ResultsOverall, the prevalence of SCCA was 61.8% in T2DM. PrFT was significantly increased in the SCCA group. Growing trends were observed in the prevalence of hypertension, carotid intima-media thickness (cIMT) > 1, plaque, and SCCA across the PrFT quartiles. Spearman correlation analysis revealed that PrFT was positively associated with cIMT (r = 0.401, p < 0.001). This correlation remained significant after adjustment for visceral fat area (VFA), subcutaneous fat area (SFA), and traditional metabolic risk factors (β = 0.184, p < 0.001). Meanwhile, PrFT was independently correlated with plaque, cIMT > 1 mm, and SCCA. The ORs (95% CI) were 1.072 (1.014–1.135), 1.319 (1.195–1.455), and 1.216 (1.119–1.322). Furthermore, PrFT remained correlated considerably with SCCA in subgroup analysis after stratification for age, sex, smoking, hypertension, and body mass index. From the ROC curve analysis, the AUCs (95% CI) of PrFT, VFA, and SFA identifying SCCA were 0.794 (0.760–0.828), 0.760 (0.724–0.796), and 0.697 (0.656–0.737), respectively. The AUC of PrFT was significantly higher than VFA (p = 0.028) and SFA (p < 0.001). The optimal cutoff values of PrFT were 14.0 mm, with a sensitivity of 66.7% and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-2392 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1276789/full; https://doaj.org/toc/1664-2392; https://doaj.org/article/1c011ee83a8b4709a6b96997ba161968 |
| DOI: | 10.3389/fendo.2023.1276789 |
| الاتاحة: | https://doi.org/10.3389/fendo.2023.1276789 https://doaj.org/article/1c011ee83a8b4709a6b96997ba161968 |
| رقم الانضمام: | edsbas.4B5BA6D8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16642392 |
|---|---|
| DOI: | 10.3389/fendo.2023.1276789 |