التفاصيل البيبلوغرافية
| العنوان: |
Obstetrical outcome and treatments in seronegative primary aps: data from european retrospective study |
| المؤلفون: |
Abisror, Noemie, Nguyen, Yann, Marozio, Luca, Esteve Valverde, Enrique, Udry, Sebastian, Pleguezuelo, Daniel Enrique, Billoir, Paul, Mayer-Pickel, Karoline, Urbanski, Geoffrey, Zigon, Polona, De Moreuil, Claire, Hoxha, Ariela, Bezanahary, Holy, Carbillon, Lionel, Kayem, Gilles, Bornes, Marie, Le Carpentier, Cécile, Johanet, Cathererine, Nicaise-Roland, Pascale, Lambert, Marc, Salle, Valery, Latino, Omar Jose, Hachulla, Eric, Benedetto, Chiara, Bourrienne, Marie Charlotte, Benhamou, Ygal, Alijotas-Reig, Jaume, Fain, Olivier, Mekinian, Arsene |
| المساهمون: |
CHU Lille, Inserm, Institut Pasteur de Lille, Université de Lille, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167, CHU Saint-Antoine AP-HP, Hôpital Beaujon AP-HP, Università degli studi di Torino = University of Turin UNITO, Hospital Universitario 12 de Octubre Madrid, Service de Médecine Interne CHU Rouen, Medical University Graz, Service de médecine interne et gérontologie clinique Angers, University Medical Centre Ljubljana Ljubljana, Slovenia UMCL, Département de Médecine Interne et Pneumologie Brest DMIP - Brest, Groupe d'Etude de la Thrombose de Bretagne Occidentale GETBO, Azienda Ospedale Università di Padova = Hospital-University of Padua AOUP, Service de Médecine interne A et polyclinique médicale CHU Limoges, Assistance publique - Hôpitaux de Paris (AP-HP) AP-HP, CHU Trousseau APHP, Sorbonne Université SU, CHU Tenon AP-HP, Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France CeRAINO, AP-HP - Hôpital Bichat - Claude Bernard Paris, CHU Amiens-Picardie, CIC - CHU Bichat, Laboratoire de Recherche Vasculaire Translationnelle LVTS (UMR_S_1148 / U1148), Vall d'Hebron University Hospital Barcelona |
| سنة النشر: |
2024 |
| المجموعة: |
LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: |
Antiphospholipid, Antibodies, Health Care, Outcome and Process Assessment, Antiphospholipid Syndrome |
| الوصف: |
To compare characteristics, pregnancies and treatments during pregnancies of seronegative and seropositive antiphospholipid syndrome (APS), to analyse factors associated with obstetrical outcome. Inclusion criteria were: (1) thrombotic and/or obstetrical APS (Sydney criteria); (2) absence of conventional antiphospholipid antibodies (APL); (3) at least one persistent non-conventional APL among IgA anticardiolipin antibodies, IgA anti-B2GPI, anti-vimentin G/M, anti-annexin V G/M, anti-phosphatidylethanolamine G/M and anti-phosphatidylserine/prothrombin G/M antibodies. The exclusion criteria were: (1) systemic lupus erythematosus ( SLE) or SLE-like disease; and (2) other connective tissue disease. A total of 187 women (mean 33±5 years) with seronegative APS were included from 14 centres in Austria, Spain, Italy, Slovenia and France and compared with 285 patients with seropositive APS. Seronegative APS has more obstetrical rather than thrombotic phenotypes, with only 6% of venous thrombosis in comparison to seropositive APS. Cumulative incidence of adverse obstetrical events was similar in seronegative and seropositive APS patients, although higher rates of intrauterine deaths (15% vs 5%; p=0.03), of preeclampsia (7% vs 16%, p=0.048) and lower live birth term (36±3 vs 38±3 weeks of gestation; p=0.04) were noted in seropositive APS. The cumulative incidence of adverse obstetrical events was significantly improved in treated versus untreated seronegative APS (log rank<0.05), whereas there was no difference between patients who received aspirin or aspirin-low-molecular weighted heparin combination. Several non-criteria APL can be detected in patients with clinical APS features without any conventional APL, with various rates. The detection of non-criteria APL and thus the diagnosis of seronegative APS could discuss the therapeutic management similar to seropositive APS, but well-designed controlled studies are necessary. ; 6 |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/rdf+xml; charset=utf-8; application/pdf |
| اللغة: |
English |
| Relation: |
RMD open; http://hdl.handle.net/20.500.12210/40804 |
| الاتاحة: |
https://hdl.handle.net/20.500.12210/40804 |
| Rights: |
Attribution-NonCommercial 3.0 United States ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.4B1A60A1 |
| قاعدة البيانات: |
BASE |