Academic Journal
Measuring disease activity and predicting response to intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy
| العنوان: | Measuring disease activity and predicting response to intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy |
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| المؤلفون: | Khoo, Anthony, Frasca, Joseph, Schultz, David |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2019 |
| المجموعة: | Flinders University, Adelaide: Flinders Academic Commons (FAC) |
| مصطلحات موضوعية: | Chronic inflammatory demyelinating polyneuropathy, Intravenous immunoglobulin, Biomarkers, Paranodal antibodies, Nerve ultrasound, Magnetic resonance neurography |
| الوصف: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ; Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterised by significant clinical heterogeneity and as such reliable biomarkers are required to measure disease activity and assess treatment response. Recent advances in our understanding of disease pathogenesis and the discovery of novel serum-based, electrophysiologic and imaging biomarkers allow clinicians to make more informed decisions regarding individualised treatment regimes. As a chronic immune-mediated process typified by relapse following withdrawal of immunomodulatory therapy, a substantial proportion of patients with CIDP require long term treatment with intravenous immunoglobulin (IVIg), a scarce and expensive donor-derived resource. The required duration and intensity of immunoglobulin treatment vary widely between individuals, highlighting both the heterogeneous nature of the underlying disease process as well as the variable pharmacologic properties of IVIg. This review outlines the use of multimodal biomarkers in the longitudinal evaluation of nerve injury and how recent developments have impacted our ability to predict both response to immunoglobulin administration and its withdrawal. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2050-7771 |
| Relation: | Khoo, A., Frasca, J., & Schultz, D. (2019). Measuring disease activity and predicting response to intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy. Biomarker Research, 7(1). https://doi.org/10.1186/s40364-019-0154-2; https://doi.org/10.1186/s40364-019-0154-2; http://hdl.handle.net/2328/38989 |
| DOI: | 10.1186/s40364-019-0154-2 |
| الاتاحة: | http://hdl.handle.net/2328/38989 https://doi.org/10.1186/s40364-019-0154-2 |
| Rights: | © The Author(s). 2019 ; The Author(s). ; CC-BY |
| رقم الانضمام: | edsbas.4B0C7B88 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20507771 |
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| DOI: | 10.1186/s40364-019-0154-2 |