Academic Journal
Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study
| العنوان: | Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study |
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| المؤلفون: | Casas Sanahuja, Maribel, Forns i Guzman, Joan, 1981-, Martínez Muriano, David, Guxens Junyent, Mònica, Fernández-Somoano, Ana, Ibarluzea, Jesús, Lertxundi, Nerea, Murcia, Mario, Rebagliato, Marisa, Tardón, Adonina, Sunyer Deu, Jordi, Vrijheid, Martine |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| مصطلحات موضوعية: | Embaràs, Neuropsicologia pediàtrica, Ensenyament preescolar |
| الوصف: | BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children's Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test. Models were adjusted for sociodemographic factors and maternal intelligence quotient. We used paternal obesity as negative control exposure as it involves the same source of confounding than maternal obesity.ResultsThe percentage of obese mothers and fathers was 8% and 12%, respectively. In unadjusted models, children of obese mothers had lower scores than children of normal weight mothers in all McCarthy subscales. After adjustment, only the verbal subscale remained statistically significantly reduced (β: -2.8; 95% confidence interval: -5.3, -0.2). No associations were observed among obese fathers. Maternal and paternal obesity were associated with an increase in ADHD-related symptoms. Parental obesity was not associated with autism symptoms.ConclusionMaternal pre-pregnancy obesity was associated with a reduction in offspring verbal scores at pre-school age. ; This study was funded by grants from European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Pediatric Research. 2017 Oct;82(4):596-606; info:eu-repo/grantAgreement/EC/FP7/282957; http://hdl.handle.net/10230/34828; http://dx.doi.org/10.1038/pr.2017.118 |
| DOI: | 10.1038/pr.2017.118 |
| الاتاحة: | http://hdl.handle.net/10230/34828 https://doi.org/10.1038/pr.2017.118 |
| Rights: | © Nature Publishing Group. http://dx.doi.org/10.1038/pr.2017.118 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4B034926 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/pr.2017.118 |
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