Academic Journal
Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol.
| العنوان: | Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol. |
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| المؤلفون: | Gallardo, Elena, Palma-Valdés, Rocío, Sarriá, Beatriz, Gallardo, Irene, de la Cruz, José P, Bravo, Laura, Mateos, Raquel, Espartero, José L |
| سنة النشر: | 2016 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Parkinson’s disease, alkyl nitrohydroxytyrosyl derivatives, antioxidant activity, hydroxytyrosol, nitrocatechol, Antioxidants, Benzothiazoles, Carbon, Fluorescence Recovery After Photobleaching, Free Radical Scavengers, Humans, Nitrogen Dioxide, Oxidation-Reduction, Oxygen, Phenol, Phenols, Phenylethyl Alcohol, Reactive Oxygen Species, Sesame Oil, Sulfonic Acids |
| الوصف: | A series of alkyl nitrohydroxytyrosyl ether derivatives has been synthesized from free hydroxytyrosol (HT), the natural olive oil phenol, in order to increase the assortment of compounds with potential neuroprotective activity in Parkinson's disease. In this work, the antioxidant activity of these novel compounds has been evaluated using Ferric Reducing Antioxidant Power (FRAP), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and Oxygen Radical Scavenging Capacity (ORAC) assays compared to that of nitrohydroxytyrosol (NO₂HT) and free HT. New compounds showed variable antioxidant activity depending on the alkyl side chain length; compounds with short chains (2-4 carbon atoms) maintained or even improved the antioxidant activity compared to NO₂HT and/or HT, whereas those with longer side chains (6-8 carbon atoms) showed lower activity than NO₂HT but higher than HT. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| Relation: | http://hdl.handle.net/10668/10117; PMC6272824; https://www.mdpi.com/1420-3049/21/5/656/pdf?version=1463570852; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272824/pdf |
| DOI: | 10.3390/molecules21050656 |
| الاتاحة: | http://hdl.handle.net/10668/10117 https://doi.org/10.3390/molecules21050656 https://www.mdpi.com/1420-3049/21/5/656/pdf?version=1463570852 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272824/pdf |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; open access |
| رقم الانضمام: | edsbas.4AD210E7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14203049 |
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| DOI: | 10.3390/molecules21050656 |