Academic Journal
Spatiotemporal summation of perimetric stimuli in healthy observers
| العنوان: | Spatiotemporal summation of perimetric stimuli in healthy observers |
|---|---|
| المؤلفون: | Montesano, G, Mulholland, PJ, Garway-Heath, DF, Evans, J, Ometto, G, Crabb, DP |
| المصدر: | Journal of Vision , 23 (4) , Article 2. (2023) |
| بيانات النشر: | Association for Research in Vision and Ophthalmology (ARVO) |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | Spatial summation of perimetric stimuli has been used to derive conclusions about the spatial extent of retinal-cortical convergence, mostly from the size of the critical area of summation (Ricco's area, RA) and critical number of retinal ganglion cells (RGCs). However, spatial summation is known to change dynamically with stimulus duration. Conversely, temporal summation and critical duration also vary with stimulus size. Such an important and often neglected spatiotemporal interaction has important implications for modeling perimetric sensitivity in healthy observers and for formulating hypotheses for changes measured in disease. In this work, we performed experiments on visually heathy observers confirming the interaction of stimulus size and duration in determining summation responses in photopic conditions. We then propose a simplified computational model that captures these aspects of perimetric sensitivity by modelling the total retinal input, the combined effect of stimulus size, duration, and retinal cones-to-RGC ratio. We additionally show that, in the macula, the enlargement of RA with eccentricity might not correspond to a constant critical number of RGCs, as often reported, but to a constant critical total retinal input. We finally compare our results with previous literature and show possible implications for modeling disease, especially glaucoma. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10168552/1/Garway-Heath_i1534-7362-23-4-2_1680516474.99924.pdf; https://discovery.ucl.ac.uk/id/eprint/10168552/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10168552/1/Garway-Heath_i1534-7362-23-4-2_1680516474.99924.pdf https://discovery.ucl.ac.uk/id/eprint/10168552/ |
| Rights: | open |
| رقم الانضمام: | edsbas.4AC7EEC3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |