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NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression

التفاصيل البيبلوغرافية
العنوان: NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression
المؤلفون: STARNES LM, SORRENTINO A, PELOSI E, BALLARINO, MONICA, MORSILLI O, BIFFONI M, SANTORO S, FELLI N, CASTELLI G, DE MARCHIS, MARIA LAURA, MASTROBERARDINO G, GABBIANELLI M, FATICA, Alessandro, BOZZONI, Irene, NERVI, Clara, PESCHLE C.
المساهمون: Starnes, Lm, Sorrentino, A, Pelosi, E, Ballarino, Monica, Morsilli, O, Biffoni, M, Santoro, S, Felli, N, Castelli, G, DE MARCHIS, MARIA LAURA, Mastroberardino, G, Gabbianelli, M, Fatica, Alessandro, Bozzoni, Irene, Nervi, Clara, Peschle, C.
بيانات النشر: AMER SOC HEMATOLOGY
سنة النشر: 2009
المجموعة: Sapienza Università di Roma: CINECA IRIS
مصطلحات موضوعية: antigen, beta-globin, biological, biosynthesi, cd34, cell differentiation, cell lineage, cytology, erythrocyte, erythropoietin, fetal blood, gene expression regulation, genetic, granulocyte colony-stimulating factor, granulocyte, hematopoietic stem cell, human, metabolism, model, nfi transcription factor, promoter region, receptors
الوصف: It is generally conceded that selective combinations of transcription factors determine hematopoietic lineage commitment and differentiation. Here we show that in normal human hematopoiesis the transcription factor nuclear factor I-A (NFI-A) exhibits a marked lineage-specific expression pattern: it is upmodulated in the erythroid (E) lineage while fully suppressed in the granulopoietic (G) series. In unilineage E culture of hematopoietic progenitor cells (HPCs), NFI-A overexpression or knockdown accelerates or blocks erythropoiesis, respectively: notably, NFI-A overexpression restores E differentiation in the presence of low or minimal erythropoietin stimulus. Conversely, NFI-A ectopic expression in unilineage G culture induces a sharp inhibition of granulopoiesis. Finally, in bilineage E + G culture, NFI-A overexpression or suppression drives HPCs into the E or G differentiation pathways, respectively. These NFI-A actions are mediated, at least in part, by a dual and opposite transcriptional action: direct binding and activation or repression of the promoters of the beta-globin and G-CSF receptor gene, respectively. Altogether, these results indicate that, in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/19542302; info:eu-repo/semantics/altIdentifier/wos/WOS:000269380600010; volume:114; issue:9; firstpage:1753; lastpage:1763; numberofpages:11; journal:BLOOD; http://hdl.handle.net/11573/230626; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-70349242211; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000269380600010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a; http://www.scopus.com/inward/record.url?eid=2-s2.0-70349242211&partnerID=65&md5=cd8147ceaa2caf835b3165e4f3b94acd
DOI: 10.1182/blood-2008-12-196196
الاتاحة: http://hdl.handle.net/11573/230626
https://doi.org/10.1182/blood-2008-12-196196
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000269380600010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a
http://www.scopus.com/inward/record.url?eid=2-s2.0-70349242211&partnerID=65&md5=cd8147ceaa2caf835b3165e4f3b94acd
رقم الانضمام: edsbas.4ABA44D1
قاعدة البيانات: BASE
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